DAP_CAT

Epidemiologic Research Group in Diabetes from Primary Health Care

The group is made up of family doctors from the Catalan Health Institute (ICS) with wide experience in the world of diabetes. All of them collaborate with other research groups or scientific societies such as the Spanish Diabetes Society, CAMFiC-SEMFyC, SEMERGEN, or CIBER-DM, and notably in coordination with the group GEDAPS Catalunya and the RedGEDAPS Espanya. It has also collaborated in drawing up the National Health System's diabetes strategy and the Diabetes mellitus type 2 Clinical Practice Guide for the Instituto de Salud Carlos III and the Ministry of Health. The Catalan Advisory Council on Diabetes systematically uses the group's data to prepare its recommendations. The group's main objective is the study of Diabetes mellitus type 2 in primary health care through epidemiological studies based on the exhaustive analysis of the data obtained from e-CAP (electronic clinical records), which will provide demographic and epidemiological information as well as better knowledge of metabolic control, the coexistence of other risk factors, the presence of complications, treatment compliance and therapeutic inertia.

Group projects

PI: Franch Nadal, Josep. A Pan-European Post-Authorisation Safety Study: Risk of Pancreatic Cancer Among Type 2 Diabetes Patients who Initiated Exenatide as Compared with those who Initiated Other non-Glucagon-Like Peptide 1 Receptor Agonists based Glucose Lowering Drugs (EXCEED). Funding: IQVIA LTD. Duration: 2020 - 2024

PI: Soldevila Madorell, Berta. Epidemiologia de diabetis gestacional i d'alteracions glucèmiques en el postpart a Catalunya. Estudi epiDMGCAT. Funding: IDIAP Jordi Gol. Duration: 2020 - 2022

PI: Mauricio Puente, Dídac. Epidemiología de SARS-CoV-2 en personas con obesidad y/o diabetes mellitus en Cataluña - Estudio epiCOVID19DMO. Funding: IDIAP Jordi Gol. Duration: 2020 - 2022

PI: Ortega Martínez de Victoria, Emilio. Epidemiología de la hipertrigliceridemia grave y su relación con la incidencia de pancreatitis aguda y enfermedad cardiovascular en Cataluña. Funding: IDIAP Jordi Gol. Duration: 2020 - 2022

Estudi del perfil i cinètica longitudinal dels anticossos al personal sanitari de la Catalunya Central infectat per SARS-CoV-2 (SERO CATCentral). Funding: . Duration: 2020 - 2021

PI: Franch Nadal, Josep. TrAtamiento Relacionado con Guias para el paciEnTe con DM2. Estudio TARGET. Funding: ICS - Institut Català de la Salut. Duration: 2020 - 2021

PI: Ortega Martínez de Victoria, Emilio. Impacto de la obesidad y/o la diabetes mellitus en personas hospitalizadas por COVID19. Funding: ICS - Institut Català de la Salut. Duration: 2020 - 2021

PI: Bundo Vidiella, Magdalena. Estudio transversal para analizar la epidemiología del pie diabético en los pacientes con diabetes mellitus tipo 2 con la base de datos SIDIAP. Funding: ICS - Institut Català de la Salut. Duration: 2019 - 2021

PI: Canivell Fusté, Silvia. Caracterización del riesgo fracturario en pacientes diabéticos mayores de 50 años tratados con SGLT2 inhibidores. Funding: ICS - Institut Català de la Salut. Duration: 2019 - 2021

PI: Mauricio Puente, Dídac. All-cause and cardio-renal-metabolic mortality in people with type 2 diabetes: a comparative international trend study. Funding: University of Leicester. Duration: 2019 - 2021

PI: López Simarro, Flora. INercia y adherencia al TratamiENto antidiabético entre los pacientes atendidos en los centroS de atención primaria en España: Estudio INTENSE. Funding: Redgedaps, s.l. Duration: 2019 - 2021

PI: Mauricio Puente, Dídac. Descubrimiento y validación de marcadores de predicción de diabetes tipo 2: proyecto colaborativo de cohortes. Funding: IDIAP Jordi Gol. Duration: 2019 - 2021

PI: Canivell Fusté, Silvia. Influencia del tratamiento antidiabético en el desarrollo de deterioro cognitivo en los pacientes diabéticos tipo 2 en Barcelona. Funding: ICS - Institut Català de la Salut. Duration: 2019 - 2021

PI: Rovira Algara, Carol. Assaig clínic multicèntric aleatoritzat obert per avaluar l? impacte de la intervenció de millora de l' adequació en l'ús de medicaments dels pacients polimedicats segons el model d' atenció centrada en la persona per un equip multidisciplinar a l'atenció primària del Bages. Funding: ICS - Institut Català de la Salut. Duration: 2019 - 2021

PI: Fernández San Martin, Maria Isabel. Efectividad de una intervención grupal psicoeducativa realizada por enfermeras de Atención Primaria en pacientes con depresión y comorbilidad física. Funding: Instituto de Salud Carlos III. Duration: 2017 - 2021

PI: Franch Nadal, Josep. Patient characteristics and cardiovascular and mortality outcomes in patients with high cardiovascular risk and type 2 diabetes mellitus initiating treatment with sodium-glucose co-transporter-2 inhibitors and other antidiabetic medications. Funding: AstraZeneca Farmacéutica Spain, S.A. Duration: 2020

PI: Franch Nadal, Josep. Importancia de la edad al diagnóstico de la diabetes tipo 2- estudio epiTempusDM2. Funding: IDIAP Jordi Gol. Duration: 2020

PI: Aguado Jodar, Alba. Xarxes de multimorbiditat , prescripció farmacèutica i factors de risc de la població adulta catalana. Estudi MorbiNet. Funding: Consorci Sanitari Integral. Duration: 2018 - 2020

PI: Franch Nadal, Josep. Estudio sobre los resultados de la adición de una sulfonilurea, un iDPP4 o un iSGLT2 como segundo antidiabético en pacientes con DM2 en tratamiento con metformina e insuficiente control glucémico. Estudio eControl Metf+. Funding: AstraZeneca Farmacéutica Spain, S.A. Duration: 2018 - 2020

PI: Olona Tabueña, Noemí. Predicció del risc cardiovascular mitjançant escales en pacients amb transtorn mental sever: estudi de cohorts retorspectiu. Funding: IDIAP Jordi Gol. Duration: 2018 - 2020

PI: Orfila Pernas, Francesc. Evaluación e intervención multimodal centrada en el paciente anciano en riesgo de resultados adversos, fragilidad y declive funcional en la comunidad. Proyecto CARTS. Funding: Instituto de Salud Carlos III. Duration: 2017 - 2020

The group participates in the following projects

PI: Fernández E. Estudio de intervención longitudinal prospectivo sobre enfermedades vasculares y renales ocultas de la cohorte ILERVAS en la provincia de Lleida. ILERVAS PLUS. El bus de la salut. Funding: ICS - Institut Català de la Salut. Duration: 2019 - 2021

The group participates in the following publications

Aguado A, Moratalla-Navarro F, López-Simarro F, Moreno V. MorbiNet: multimorbidity networks in adult general population. Analysis of type 2 diabetes mellitus comorbidity. Sci Rep. 2020 Feb; 10(1):2416. doi:10.1038/s41598-020-59336-1. Epub 2020 Feb 12. PMID:32051506. IF: 3,998.

Alcubierre N, Granado-Casas M, Real J, Perpiñán H, Rubinat E, Falguera M, Castelblanco E, Franch-Nadal J, Mauricio D. Spanish People with Type 2 Diabetes Show an Improved Adherence to the Mediterranean Diet. Nutrients. 2020 Feb; 12(2). doi:10.3390/nu12020560. Epub 2020 Feb 20. pmc:PMC7071466. PMID:32093385. IF: 4,546.

Amor AJ, Castelblanco E, Hernández M, Gimenez M, Granado-Casas M, Blanco J, Soldevila B, Esmatjes E, Conget I, Alonso N, Ortega E, Mauricio D. Advanced lipoprotein profile disturbances in type 1 diabetes mellitus: a focus on LDL particles. Cardiovasc Diabetol. 2020 Aug; 19(1):126. doi:10.1186/s12933-020-01099-0. Epub 2020 Aug 09. pmc:PMC7416413. PMID:32772924. IF: 7,332.

Bermúdez-López M, Martínez-Alonso M, Castro-Boqué E, Betriu À, Cambray S, Farràs C, Barbé F, Pamplona R, Lecube A, Mauricio D, Purroy F, Valdivielso JM, Fernández E; ILERVAS project collaborators. Subclinical atheromatosis localization and burden in a low-to-moderate cardiovascular risk population: the ILERVAS study. Rev Esp Cardiol (Engl Ed). 2020 Nov; doi:10.1016/j.rec.2020.09.015. Epub 2020 Nov 05. PMID:33162389.

Buil-Cosiales P, Gómez-García C, Cos X, Franch-Nadal J, Vlacho B, Millaruelo JM. [Poor awareness among health care professionals about gender differences in the relationship between type 2 diabetes mellitus and cardiovascular disease]. Semergen. 2020 Mar; 46(2):90-100. doi:10.1016/j.semerg.2019.10.002. Epub 2019 Dec 10. Spanish. PMID:31831323.

Castelblanco E, Sanjurjo L, Barranco-Altirriba M, Falguera M, Hernández M, Soldevila B, Sarrias MR, Franch-Nadal J, Arroyo JA, Fernandez-Real JM, Alonso N, Mauricio D. The Circulating Fatty Acid Transporter Soluble CD36 Is Not Associated with Carotid Atherosclerosis in Subjects with Type 1 and Type 2 Diabetes Mellitus. J Clin Med. 2020 Jun; 9(6). doi:10.3390/jcm9061700. Epub 2020 Jun 02. pmc:PMC7355534. PMID:32498389. IF: 3,303.

Cebrián-Cuenca AM, Mata-Cases M, Franch-Nadal J, Mauricio D, Orozco-Beltrán D, Consuegra-Sánchez L. Half of patients with type 2 diabetes mellitus are at very high cardiovascular risk according to the ESC/EASD: data from a large Mediterranean population. Eur J Prev Cardiol. 2020 Nov; doi:10.1093/eurjpc/zwaa073. Epub 2020 Nov 14. PMID:33733654. IF: 5,864.

Cos X, Seidu S, Brunton S, Harris SB, Jansson SPO, Mata-Cases M, Neijens AMJ, Topsever P, Khunti K. TEMPORARY REMOVAL: Impact on guidelines: the general practitioner point of view. Diabetes Res. Clin. Pract. 2020 Feb; doi:10.1016/j.diabres.2020.108091. Epub 2020 Feb 24. PMID:32105769. IF: 4,234.

Díaz-Cerezo S, Romera I, Sicras-Mainar A, López-Simarro F, Dilla T, Artime E, Reviriego J. Resource use and costs in patients with poorly controlled type 2 diabetes mellitus and obesity in routine clinical practice in Spain. Curr Med Res Opin. 2020 Sep; 36(9):1449-1456. doi:10.1080/03007995.2020.1793749. Epub 2020 Jul 23. PMID:32643441. IF: 2,271.

Escribano-Serrano J, Michán-Doña A, López-Simarro F. The importance of the cut-off point for considering good adherence in diabetes. Med Clin (Barc). 2020 11; 155(10):467-468. doi:10.1016/j.medcli.2019.07.028. Epub 2020 Mar 17. PMID:32197863. IF: 1,635.

Falguera M, Vilanova MB, Alcubierre N, Granado-Casas M, Marsal JR, Miró N, Cebrian C, Molló À, Franch-Nadal J, Mata-Cases M, Castelblanco E, Mauricio D. Prevalence of pre-diabetes and undiagnosed diabetes in the Mollerussa prospective observational cohort study in a semi-rural area of Catalonia. BMJ Open. 2020 Jan; 10(1):e033332. doi:10.1136/bmjopen-2019-033332. Epub 2020 Jan 20. pmc:PMC7044846. PMID:31964673. IF: 2,496.

Gómez García MC, Franch-Nadal J, Millaruelo Trillo JM, Cos-Claramunt FX, Avila Lachica L, Buil Cosiales P. [Blood glucose control and cardiovascular risk factors in type 2 diabetic patients with cardiovascular disease in Spain, and its treatment pattern, according to gender: CODICE study]. Semergen. 2020 Mar; 46(2):125-135. doi:10.1016/j.semerg.2019.05.005. Epub 2019 Aug 06. Spanish. PMID:31399388.

Gómez García MC, Millaruelo Trillo JM, Avila Lachica L, Cos-Claramunt FX, Franch-Nadal J, Cortés Gil X. [ESCRYTO study. Diabetes without cardiovascular disease and level of control]. Semergen. 2020 May; 46(4):261-269. doi:10.1016/j.semerg.2019.11.006. Epub 2019 Dec 23. Spanish. PMID:31874786.

Jiménez-Balado J, Riba-Llena I, Maisterra O, Pizarro J, Palasí A, Pujadas F, Mundet X, Vinyoles E, Delgado P. Ambulatory Blood Pressure Levels in the Prediction of Progression of Cerebral Small Vessel Disease. J Am Geriatr Soc. 2020 Oct; 68(10):2232-2239. doi:10.1111/jgs.16568. Epub 2020 Jun 08. PMID:32511756. IF: 4,180.

Kohsaka S, Lam CSP, Kim DJ, Cavender MA, Norhammar A, Jørgensen ME, Birkeland KI, Holl RW, Franch-Nadal J, Tangri N, Shaw JE, Ilomäki J, Karasik A, Goh SY, Chiang CE, Thuresson M, Chen H, Wittbrodt E, Bodegård J, Surmont F, Fenici P, Kosiborod M; CVD-REAL 2 Investigators and Study Group. Risk of cardiovascular events and death associated with initiation of SGLT2 inhibitors compared with DPP-4 inhibitors: an analysis from the CVD-REAL 2 multinational cohort study. Lancet Diabetes Endocrinol. 2020 07; 8(7):606-615. doi:10.1016/S2213-8587(20)30130-3. PMID:32559476. IF: 25,340.

Lacasta Tintorer D, Manresa Domínguez JM, Jiménez-Zarco A, Rodríguez-Blanco T, Flayeh Beneyto S, Torán-Monserrat P, Mundet Tuduri X, Saigí-Rubió F. Efficiency as a determinant of loyalty among users of a Community of Clinical Practice: a comparative study between the implementation and consolidation phases. BMC Fam Pract. 2020 01; 21(1):15. doi:10.1186/s12875-020-1081-x. Epub 2020 Jan 24. pmc:PMC6979059. PMID:31980016. IF: 2,022.

Martinez-Gonzalez D, Dòria M, Martínez-Alonso M, Alcubierre N, Valls J, Verdú-Soriano J, Granado-Casas M, Mauricio D. Adaptation and Validation of the Diabetic Foot Ulcer Scale-Short Form in Spanish Subjects. J Clin Med. 2020 Aug; 9(8). doi:10.3390/jcm9082497. Epub 2020 Aug 03. pmc:PMC7465700. PMID:32756508. IF: 3,303.

Mata-Cases M, Franch-Nadal J, Gratacòs M, Mauricio D. Therapeutic Inertia: Still a Long Way to Go That Cannot Be Postponed. Diabetes Spectr. 2020 Feb; 33(1):50-57. doi:10.2337/ds19-0018. pmc:PMC7026756. PMID:32116454.

Mata-Cases M, Mahon J, Mauricio D, Franch-Nadal J, Real J, Hex N. Improving management of glycaemic control in people with T2DM in primary care: estimation of the impact on the clinical complications and associated costs. BMC Health Serv Res. 2020 Aug; 20(1):803. doi:10.1186/s12913-020-05360-w. Epub 2020 Aug 26. pmc:PMC7448435. PMID:32847581. IF: 1,987.

Mata-Cases M, Rodríguez-Sánchez B, Mauricio D, Real J, Vlacho B, Franch-Nadal J, Oliva J. The Association Between Poor Glycemic Control and Health Care Costs in People With Diabetes: A Population-Based Study. Diabetes Care. 2020 04; 43(4):751-758. doi:10.2337/dc19-0573. Epub 2020 Feb 06. PMID:32029636. IF: 16,019.

Mauricio D, Alonso N, Gratacòs M. Chronic Diabetes Complications: The Need to Move beyond Classical Concepts. Trends Endocrinol. Metab. 2020 Apr; 31(4):287-295. doi:10.1016/j.tem.2020.01.007. Epub 2020 Feb 04. PMID:32033865. IF: 11,641.

Moratalla-Navarro F, Moreno V, López-Simarro F, Aguado A. MorbiNet study. Hypothyroidism comorbidity networks in the adult general population. J Clin Endocrinol Metab. 2020 Dec; doi:10.1210/clinem/dgaa927. Epub 2020 Dec 15. PMID:33319230. IF: 5,399.

Navas-Madroñal M, Castelblanco E, Camacho M, Consegal M, Ramirez-Morros A, Sarrias MR, Perez P, Alonso N, Galán M, Mauricio D. Role of the Scavenger Receptor CD36 in Accelerated Diabetic Atherosclerosis. Int J Mol Sci. 2020 Oct; 21(19). doi:10.3390/ijms21197360. Epub 2020 Oct 05. pmc:PMC7583063. PMID:33028031. IF: 4,556.

Parrizas M, Mundet X, Castaño C, Canivell S, Cos X, Brugnara L, Giráldez-García C, Regidor E, Mata-Cases M, Franch-Nadal J, Novials A. miR-10b and miR-223-3p in serum microvesicles signal progression from prediabetes to type 2 diabetes. J. Endocrinol. Invest. 2020 Apr; 43(4):451-459. doi:10.1007/s40618-019-01129-z. Epub 2019 Nov 12. PMID:31721085. IF: 3,397.

Rojo-Martínez G, Valdés S, Soriguer F, Vendrell J, Urrutia I, Pérez V, Ortega E, Ocón P, Montanya E, Menéndez E, Lago-Sampedro A, González-Frutos T, Gomis R, Goday A, García-Serrano S, García-Escobar E, Galán-García JL, Castell C, Badía-Guillén R, Aguilera-Venegas G, Girbés J, Gaztambide S, Franch-Nadal J, Delgado E, Chaves FJ, Castaño L, Calle-Pascual A. Incidence of diabetes mellitus in Spain as results of the nation-wide cohort di@bet.es study. Sci Rep. 2020 Feb; 10(1):2765. doi:10.1038/s41598-020-59643-7. Epub 2020 Feb 17. pmc:PMC7026031. PMID:32066839. IF: 3,998.

Romera I, Díaz S, Sicras-Mainar A, López-Simarro F, Dilla T, Artime E, Reviriego J. Clinical Inertia in Poorly Controlled Type 2 Diabetes Mellitus Patients with Obesity: An Observational Retrospective Study. Diabetes Ther. 2020 Feb; 11(2):437-451. doi:10.1007/s13300-019-00745-5. Epub 2019 Dec 28. pmc:PMC6995792. PMID:31884573. IF: 3,179.

Tintorer DL, Domínguez JMM, Jiménez-Zarco A, Rodríguez-Blanco T, Beneyto SF, Torán-Monserrat P, Tuduri XM, Saigí-Rubió F. Correction to: Efficiency as a determinant of loyalty among users of a Community of Clinical Practice: a comparative study between the implementation and consolidation phases. BMC Fam Pract. 2020 Apr; 21(1):65. doi:10.1186/s12875-020-01133-w. Epub 2020 Apr 17. pmc:PMC7164183. PMID:32303213. IF: 2,022.

Tintorer DL, Domínguez JMM, Pujol-Rivera E, Beneyto SF, Tuduri XM, Saigí-Rubió F. Correction to: Keys to success of a community of clinical practice in primary care: a qualitative evaluation of the ECOPIH project. BMC Fam Pract. 2020 Apr; 21(1):64. doi:10.1186/s12875-020-01132-x. Epub 2020 Apr 17. pmc:PMC7164276. PMID:32303187. IF: 2,022.

Vilanova MB, Franch-Nadal J, Falguera M, Marsal JR, Canivell S, Rubinat E, Miró N, Molló À, Mata-Cases M, Gratacòs M, Castelblanco E, Mauricio D. Prediabetes Is Independently Associated with Subclinical Carotid Atherosclerosis: An Observational Study in a Non-Urban Mediterranean Population. J Clin Med. 2020 Jul; 9(7). doi:10.3390/jcm9072139. Epub 2020 Jul 07. pmc:PMC7408832. PMID:32645918. IF: 3,303.

Vlacho B, Mundet X, Mata J, Vallès J, Real J, Cos F, Mauricio D, Franch J. Analysis of the effectiveness of second oral glucose-lowering therapy in routine clinical practice from the Mediterranean area: A retrospective cohort study. Diabetes Res Clin Pract. 2020;Volume 171:108616. PMID:33310172. IF: 4,234.

Indicators

Indicator

2020

Researchers with PhD

8

Total number of projects in which group members have participated

22

Total number of projects in which the PI of the project has belonged to the group

11

Total Funding

433.219 €

Scientific publications in indexed journals

25

Total Impact factor

132,28

Nº of articles in Q1 journals

16

Q1 IF

111,25

Nº of articles in Q2 journals

6

Q2 IF

14,23

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