Research Group on Health Economics in Primary Care

Multidisciplinary group composed of six general practitioners (3 of them are also doctors in medicine), a nurse practitioner, three doctors in psychology, two doctors in pharmacy, two pharmacy graduates and a doctor in psychiatry. The group originated in 1999 under the name GRAPISAM Group (Research Group in Primary Care and Mental Health) with the development of the DAPGA study that was carried out in the Mental Health Center of Gavà and the ABS Bartolomé Fabrés Anglada of Gavà. As a result of that first collaboration, others emerged, such as the ETAPS, FIBROQOL and PRODEFAR studies, which focused mainly on the evaluation of interventions aimed at the management of mental illnesses in primary care, always with a focus on health economics. In recent years, the group has grown, becoming more multidisciplinary, expanding the focus of research and increasingly specializing in the economic evaluation of health in primary care, including the evaluation of the economic impact of diseases (eg COSTDEP), the cost-effectiveness of preventive interventions (eg PREDICTD-CCRT), the cost-effectiveness of pharmacological treatments (eg INFAP) and non-pharmacological treatments (eg EUDAIMON), the cost of non-adherence and the impact of the introduction of health policies (eg NO-Iniciadores), etc. In addition, although the study of mental illnesses is still one of the main focuses of the group, the research has been extended to other pathologies, such as the management of chronic pain and fibromyalgia (eg Fibromyalgia subtypes and EUDAIMON) or multi-risk prevention (eg Econ-EIRA3). The group complements the use of clinical trials and economic evaluations with other study designs that allow it to better understand the difficulties of managing pathologies in primary care and the efficiency of treatments, such as psychometric analysis (WHODAS 2.0, CERQ, FFMQ, MISCI, etc.), qualitative research (eg, PREDICT-EVAL), systematic reviews (eg EIRA2), and epidemiological studies based on the secondary exploitation of large databases, such as SIDIAP, all within the framework of research in the field of primary care. This evolution has given way to the Research Group on Health Economics in Primary Care (ECONSAP). The main objectives of the group are to improve the quality and efficiency of mental pathologies and chronic physical diseases care in Primary Care - including prevention and pharmacological and non-pharmacological treatment -, to assess the cost of diseases and patients? behavior and to develop innovative and multidisciplinary interventions in the area of Primary Care from a multidisciplinary point of view.

Group projects

PI: Luciano Devis, Juan Vicente. Coste-utilidad y efectos fisiológicos de la Terapia de Aceptación y Compromiso y la Activación Conductual en pacientes con dolor crónico y depresión mayor comórbida (Proyecto IMPACT). Funding: Instituto de Salud Carlos III. Duration: 2020 - 2022

PI: Vicens Pons, Enric. Cohorte DESVELA. Análisis del papel de las aptitudes personales como DEterminantes de la incidencia de morbilidad, eStilos de vida, calidad de Vida, uso de sErvicios y mortaLidAd. Funding: Instituto de Salud Carlos III. Duration: 2020 - 2022

PI: Rubio Valera, Maria. Pilot d'una intervenció complexa per millorar la iniciació al tractament farmacològic. Funding: Fundació per a la recerca i la docència Sant Joan de Déu (FSJD). Duration: 2020 - 2022

PI: Mendive Arbeloa, Juan Manuel. Developing, implementing and evaluating a clinical care pathway for NASH primary care patients: a multi-centre study. Duration: 2020 - 2022

PI: Rubio Valera, Maria. El problema de la no iniciación pedíatrica: Evaluación con métodos mixtos. Funding: Instituto de Salud Carlos III. Duration: 2020 - 2022

PI: Mendive Arbeloa, Juan Manuel. Prevención de la depresión a través de una intervención personalizada basada en TICs, algoritmos predictivos de riesgo, y DSS para pacientes y médicos de familia: El estudio e-predictD. Funding: ICS - Institut Català de la Salut. Duration: 2020 - 2022

PI: Bellon Saameño, Juan Angel. Prevención universal de la depresión y ansiedad en población general mediante una intervención personalizada basada en algoritmos de riesgo, TICs y sistemas de ayuda a las decisiones: ensayo controlado aleatorio. El estudio PredictPlusPrevent. Funding: Junta de Andalucia. Duration: 2019 - 2022

PI: Bellon Saameño, Juan Angel. Prevención de la depresión en el medio laboral mediante una intervención personalizada basada en algoritmos de riesgo, TICs y sistemas de ayuda a las decisiones: ensayo controlado aleatorio. Funding: Instituto de Salud Carlos III. Duration: 2019 - 2021

PI: Luciano Devis, Juan Vicente. Efectos del peregrinaje en el Camino de Santiago sobre el bienestar psicológico y la salud mental. Funding: Fundació per a la recerca i la docència Sant Joan de Déu (FSJD). Duration: 2019 - 2021

PI: Mendive Arbeloa, Juan Manuel. Suport social i el seu impacte a la salut en el barri de La Mina: Seguiment i ampliació d'una cohort poblacional. Funding: ICS - Institut Català de la Salut. Duration: 2019 - 2020

PI: Rubio Valera, Maria. A non-interventional post-authorisation safety study (PASS) of vortioxetine in Europe An analysis of SIDIAP Database from Catalonia, Spain. Funding: H. Lundbeck A/S. Duration: 2018 - 2020

PI: Luciano Devis, Juan Vicente. Cost-effectiveness of a Mindfulness-Based Stress Reduction (MBSR) treatment for fibromyalgia syndrome: A 12-month randomised, controlled trial. Funding: Instituto de Salud Carlos III. Duration: 2015 - 2020

Group Publications

Sanabria-Mazo JP, Montero-Marin J, Feliu-Soler A, Gasión V, Navarro-Gil M, Morillo-Sarto H, Colomer-Carbonell A, Borràs X, Tops M, Luciano JV, García-Campayo J. Mindfulness-Based Program Plus Amygdala and Insula Retraining (MAIR) for the Treatment of Women with Fibromyalgia: A Pilot Randomized Controlled Trial. J Clin Med. 2020 Oct; 9(10). doi:10.3390/jcm9103246. Epub 2020 Oct 11. pmc:PMC7599726. PMID:33050630. IF: 3,303.

Angarita-Osorio N, Pérez-Aranda A, Feliu-Soler A, Andrés-Rodríguez L, Borràs X, Suso-Ribera C, Slim M, Herrera-Mercadal P, Fernández-Vergel R, Blanco ME, Luciano JV. Patients With Fibromyalgia Reporting Severe Pain but Low Impact of the Syndrome: Clinical and Pain-Related Cognitive Features. Pain Pract. 2020 Mar; 20(3):255-261. doi:10.1111/papr.12847. Epub 2019 Nov 11. PMID:31627253. IF: 2,258.

Arias-de la Torre J, Puigdomenech E, García X, Valderas JM, Eiroa-Orosa FJ, Fernández-Villa T, Molina AJ, Martín V, Serrano-Blanco A, Alonso J, Espallargues M. Relationship Between Depression and the Use of Mobile Technologies and Social Media Among Adolescents: Umbrella Review. J Med Internet Res. 2020 08; 22(8):e16388. doi:10.2196/16388. Epub 2020 Aug 26. pmc:PMC7481866. PMID:32663157. IF: 5,034.

Arias-de la Torre J, Vilagut G, Serrano-Blanco A, Martín V, Molina AJ, Valderas JM, Alonso J. Accuracy of Self-Reported Items for the Screening of Depression in the General Population. Int J Environ Res Public Health. 2020 10; 17(21). doi:10.3390/ijerph17217955. Epub 2020 Oct 29. pmc:PMC7662518. PMID:33138196. IF: 2,849.

Bellón JA, Conejo-Cerón S, Rodríguez-Bayón A, Ballesta-Rodríguez MI, Mendive JM, Moreno-Peral P. [Common mental disorders in primary care: diagnostic and therapeutic difficulties, and new challenges in prediction and prevention. SESPAS Report 2020]. Gac Sanit. 2020 ; 34 Suppl 1:20-26. doi:10.1016/j.gaceta.2020.05.013. Epub 2020 Aug 22. Spanish. PMID:32843196. IF: 1,564.

Casellas F, Guinard Vicens D, García-López S, González-Lama Y, Argüelles-Arias F, Barreiro-de Acosta M, Marín Sánchez L, Mendive JM, Saldaña R, Cabez A, Gómez S, Loza E. Consensus document on the management preferences of patients with ulcerative colitis: points to consider and recommendations. Eur J Gastroenterol Hepatol. 2020 Dec; 32(12):1514-1522. doi:10.1097/MEG.0000000000001885. PMID:32804838. IF: 2,251.

D'Amico F, Feliu-Soler A, Montero-Marín J, Peñarrubía-María MT, Navarro-Gil M, Van Gordon W, García-Campayo J, Luciano JV. Cost-Utility of Attachment-Based Compassion Therapy (ABCT) for Fibromyalgia Compared to Relaxation: A Pilot Randomized Controlled Trial. J Clin Med. 2020 Mar; 9(3). doi:10.3390/jcm9030726. Epub 2020 Mar 07. pmc:PMC7141201. PMID:32156065. IF: 3,303.

Demarzo M, García-Campayo J, Martínez-Rubio D, Pérez-Aranda A, Miraglia JL, Hirayama MS, de Salvo VMA, Cicuto K, Favarato ML, Terra V, de Oliveira MB, García-Toro M, Modrego-Alarcón M, Montero-Marín J. Frenetic, under-Challenged, and Worn-out Burnout Subtypes among Brazilian Primary Care Personnel: Validation of the Brazilian "Burnout Clinical Subtype Questionnaire" (BCSQ-36/BCSQ-12). Int J Environ Res Public Health. 2020 02; 17(3). doi:10.3390/ijerph17031081. Epub 2020 Feb 08. pmc:PMC7036968. PMID:32046282. IF: 2,849.

Feliu-Soler A, Martínez-Zalacaín I, Pérez-Aranda A, Borràs X, Andrés-Rodríguez L, Sanabria-Mazo JP, Fayed N, Stephan-Otto C, Núñez C, Soriano-Mas C, Luciano JV. The Bed Nucleus of the Stria Terminalis as a Brain Correlate of Psychological Inflexibility in Fibromyalgia. J Clin Med. 2020 Jan; 9(2). doi:10.3390/jcm9020374. Epub 2020 Jan 30. pmc:PMC7074535. PMID:32019063. IF: 3,303.

Gil-Girbau M, Aznar-Lou I, Peñarrubia-María MT, Moreno-Peral P, Fernández A, Bellón JÁ, Jové AM, Mendive J, Fernández-Vergel R, Figueiras A, March-Pujol M, Rubio-Valera M. Reasons for medication non-initiation: A qualitative exploration of the patients' perspective. Res Social Adm Pharm. 2020 May; 16(5):663-672. doi:10.1016/j.sapharm.2019.08.002. Epub 2019 Aug 06. PMID:31402307. IF: 2,844.

Hernández S, Navas E, Aznar-Lou I, Ciruela P, García-García JJ, Moraga-Llop F, Muñoz-Almagro C, Codina G, F de Sevilla M, González-Peris S, Esteva C, Planes AM, Izquierdo C, Martínez-Osorio J, Campins M, Uriona S, Salleras L, Serrano-Blanco A, Jané M, Domínguez Á. Impact of the 13-Valent Conjugated Pneumococcal Vaccine on the Direct Costs of Invasive Pneumococcal Disease Requiring Hospital Admission in Children Aged < 5 Years: A Prospective Study. Vaccines (Basel). 2020 Jul; 8(3). doi:10.3390/vaccines8030387. Epub 2020 Jul 15. pmc:PMC7564806. PMID:32679762. IF: 4,086.

ieto R, Pardo R, Sora B, Feliu-Soler A, Luciano JV. Impact of COVID-19 Lockdown Measures on Spanish People with Chronic Pain: An Online Study Survey. J Clin Med. 2020 Nov; 9(11). doi:10.3390/jcm9113558. Epub 2020 Nov 05. pmc:PMC7694344. PMID:33167322. IF: 3,303.

Martínez-Rubio D, Sanabria-Mazo JP, Feliu-Soler A, Colomer-Carbonell A, Martínez-Brotóns C, Solé S, Escamilla C, Giménez-Fita E, Moreno Y, Pérez-Aranda A, Luciano JV, Montero-Marín J. Testing the Intermediary Role of Perceived Stress in the Relationship between Mindfulness and Burnout Subtypes in a Large Sample of Spanish University Students. Int J Environ Res Public Health. 2020 09; 17(19). doi:10.3390/ijerph17197013. Epub 2020 Sep 25. pmc:PMC7579009. PMID:32992782. IF: 2,849.

Parody E, Rubio M, Gómez A, Casajuana M, Carbonell C, Aznar I. Economic Evaluations Informed Exclusively by Real World Data: A Systematic Review. Int J Environ Res Public Health. 2020;17:E1171-E1171. PMID:32059593. IF: 2,849.

Pérez-Aranda A, Feliu-Soler A, Mist SD, Jones KD, López-Del-Hoyo Y, Oliván-Arévalo R, Kratz A, Williams DA, Luciano JV. Subgrouping a Large U.S. Sample of Patients with Fibromyalgia Using the Fibromyalgia Impact Questionnaire-Revised. Int J Environ Res Public Health. 2020 12; 18(1). doi:10.3390/ijerph18010247. Epub 2020 Dec 31. pmc:PMC7796452. PMID:33396279. IF: 2,849.

Perez-Cruzado D, Vera-Garcia E, Mayoral-Cleries F, Luciano JV, Cuesta-Vargas A. Adaptation and validation of a scale of self-efficacy and social support for physical activity in Spanish patients with severe mental disorders. Brain Behav. 2020 Feb; 10(2):e01510. doi:10.1002/brb3.1510. Epub 2019 Dec 26. pmc:PMC7010581. PMID:31880097. IF: 2,091.

rias de la Torre J, Vilagut G, Ronaldson A, Dregan A, Ricci-Cabello I, Hatch SL, Serrano-Blanco A, Valderas JM, Hotopf M, Alonso J. Prevalence and age patterns of depression in the United Kingdom. A population-based study. J Affect Disord. 2021 Jan; 279:164-172. doi:10.1016/j.jad.2020.09.129. Epub 2020 Oct 07. PMID:33059219. IF: 3,892.

Sanabria-Mazo JP, Forero CG, Cristobal-Narváez P, Suso-Ribera C, García-Palacios A, Colomer-Carbonell A, Pérez-Aranda A, Andrés-Rodríguez L, McCracken LM, D'Amico F, Estivill-Rodríguez P, Carreras-Marcos B, Montes-Pérez A, Comps-Vicente O, Esteve M, Grasa M, Rosa A, Cuesta-Vargas AI, Maes M, Borràs X, Edo S, Sanz A, Feliu-Soler A, Castaño-Asins JR, Luciano JV. Efficacy, cost-utility and physiological effects of Acceptance and Commitment Therapy (ACT) and Behavioural Activation Treatment for Depression (BATD) in patients with chronic low back pain and depression: study protocol of a randomised, controlled trial including mobile-technology-based ecological momentary assessment (IMPACT study). BMJ Open. 2020 07; 10(7):e038107. doi:10.1136/bmjopen-2020-038107. Epub 2020 Jul 23. pmc:PMC7380881. PMID:32709656. IF: 2,496.

Serra J, Pohl D, Azpiroz F, Chiarioni G, Ducrotté P, Gourcerol G, Hungin APS, Layer P, Mendive JM, Pfeifer J, Rogler G, Scott SM, Simrén M, Whorwell P; Functional Constipation Guidelines Working Group. European society of neurogastroenterology and motility guidelines on functional constipation in adults. Neurogastroenterol. Motil. 2020 02; 32(2):e13762. doi:10.1111/nmo.13762. Epub 2019 Nov 22. PMID:31756783. IF: 2,946.

Serrat M, Almirall M, Musté M, Sanabria-Mazo JP, Feliu-Soler A, Méndez-Ulrich JL, Luciano JV, Sanz A. Effectiveness of a Multicomponent Treatment for Fibromyalgia Based on Pain Neuroscience Education, Exercise Therapy, Psychological Support, and Nature Exposure (NAT-FM): A Pragmatic Randomized Controlled Trial. J Clin Med. 2020 Oct; 9(10). doi:10.3390/jcm9103348. Epub 2020 Oct 18. pmc:PMC7603188. PMID:33081069. IF: 3,303.

Serrat M, Sanabria-Mazo JP, García-Troiteiro E, Fontcuberta A, Mateo-Canedo C, Almirall M, Feliu-Soler A, Méndez-Ulrich JL, Sanz A, Luciano JV. Efficacy of a Multicomponent Intervention for Fibromyalgia Based on Pain Neuroscience Education, Exercise Therapy, Psychological Support, and Nature Exposure (NAT-FM): Study Protocol of a Randomized Controlled Trial. Int J Environ Res Public Health. 2020 01; 17(2). doi:10.3390/ijerph17020634. Epub 2020 Jan 19. pmc:PMC7013723. PMID:31963773. IF: 2,849.

Vilaplana-Carnerero C, Aznar-Lou I, Peñarrubia-María MT, Serrano-Blanco A, Fernández-Vergel R, Petitbò-Antúnez D, Gil-Girbau M, March-Pujol M, Mendive JM, Sánchez-Viñas A, Carbonell-Duacastella C, Rubio-Valera M. Initiation and Single Dispensing in Cardiovascular and Insulin Medications: Prevalence and Explanatory Factors. Int J Environ Res Public Health. 2020 05; 17(10). doi:10.3390/ijerph17103358. Epub 2020 May 12. pmc:PMC7277594. PMID:32408626. IF: 2,849.




Researchers with PhD


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Total Funding

749.215,86 €

Scientific publications in indexed journals


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