Infections in Primary Care Research Group

The primary objective of the group is to define a policy of antibiotics in primary care, in order to achieve a more reasoned prescription of antibiotics in infectious diseases in primary care, identifying the subgroups of patients who really need them . Other objectives are the microbiological aspects of the most prevalent community germs, to diagnose precisely the different infectious processes with the help of rapid diagnostic methods, to better identify whether the aetiology is bacterial or viral and to better understand the level of resistances of common microorganisms. The group is made up of family doctors who work in different lines of research for infectious diseases in primary care. It is planned in the future to also have professionals in the field of microbiology, pneumology, nursing staff and statisticians. We have collaborations with: hospitals (Vall d'Hebron Hospital in Barcelona and Joan XXIII Hospital in Tarragona), universities (University of Barcelona, Autonomous University of Barcelona, Rovira i Virgili University, University of Cardiff, University of Oxford and University of Copenhagen) and scientific societies (Camfic, semFYC and WONCA). This group includes GPs that investigate various aspects of infectious diseases in primary care, together with other professionals such as specialists in respiratory diseases, nurses and statisticians.

The group participates in the following projects

PI: Llor Vilà, Carles. Effectiveness and cost-effectiveness of Improving clinicians' diagnostic and communication Skills on Antibiotic prescribing Appropriateness in patients with acute Cough in primary care in CATalonia. Funding: Fundacio La Marato de TV3. Duration: 2019 - 2022

PI: Llor Vilà, Carles. Intervention Study - Effectiveness and cost-effectiveness of Improving clinicians' diagnostic and communication Skills on Antibiotic prescribing Appropriateness in patients with acute Cough in primary care in CATalonia. Funding: ICS - Institut Català de la Salut. Duration: 2019 - 2022

PI: Llor Vilà, Carles. Efectividad del tratamiento antitusígeno, anticolinérgico y miel versus práctica habitual en adultos con bronquitis aguda no complicada. Funding: Instituto de Salud Carlos III. Duration: 2018 - 2022

PI: Llor Vilà, Carles. SARS-CoV-2 Observational Study of community acquired acute respiratory tract infection during a time of widespread suspected COVID-19 in European primary care. Funding: UMC Utrecht (University Medical Center Utrecht). Duration: 2020

PI: Llor Vilà, Carles. Community acquired acute respiratory tract infection (CA-ARTI) in community care in Europe: point prevalence audit study (PPAS) of presentation and management. Funding: University of Oxford. Duration: 2019 - 2020

The group participates in the following publications

Baena-Díez JM, Pinnegar HP, Paredes-Millán MK, Plaza-Cerrato L, Palomino-Español E, Cots JM. [Incidence of SARS-CoV-2 infection in close contacs. Telephone follow-up in Primary Care]. Med Clin (Barc). 2021 05; 156(9):444-446. doi:10.1016/j.medcli.2020.11.003. Epub 2020 Dec 03. pmc:PMC7713603. PMID:33358434. IF: 1,635.

Butler CC, van der Velden AW, Bongard E, Saville BR, Holmes J, Coenen S, Cook J, Francis NA, Lewis RJ, Godycki-Cwirko M, Llor C, Chlabicz S, Lionis C, Seifert B, Sundvall PD, Colliers A, Aabenhus R, Bjerrum L, Jonassen Harbin N, Lindbæk M, Glinz D, Bucher HC, Kovács B, Radzeviciene Jurgute R, Touboul Lundgren P, Little P, Murphy AW, De Sutter A, Openshaw P, de Jong MD, Connor JT, Matheeussen V, Ieven M, Goossens H, Verheij TJ. Oseltamivir plus usual care versus usual care for influenza-like illness in primary care: an open-label, pragmatic, randomised controlled trial. Lancet. 2020 01; 395(10217):42-52. doi:10.1016/S0140-6736(19)32982-4. Epub 2019 Dec 12. PMID:31839279. IF: 60,390.

Esquinas C, Ramon MA, Nuñez A, Molina J, Quintano JA, Roman-Rodríguez M, Naberan K, Llor C, Roncero C, Miravitlles M, Barrecheguren M. Correlation between disease severity factors and EQ-5D utilities in chronic obstructive pulmonary disease. Qual Life Res. 2020 Mar; 29(3):607-617. doi:10.1007/s11136-019-02340-4. Epub 2019 Oct 31. PMID:31673922. IF: 2,773.

Francis NA, Gillespie D, White P, Bates J, Lowe R, Sewell B, Phillips R, Stanton H, Kirby N, Wootton M, Thomas-Jones E, Hood K, Llor C, Cals J, Melbye H, Naik G, Gal M, Fitzsimmons D, Alam MF, Riga E, Cochrane A, Butler CC. C-reactive protein point-of-care testing for safely reducing antibiotics for acute exacerbations of chronic obstructive pulmonary disease: the PACE RCT. Health Technol Assess. 2020 Mar; 24(15):1-108. doi:10.3310/hta24150. PMID:32202490. IF: 3,370.

Llor C, Miravitlles M. C-reactive protein point of care testing: the answer to antibiotic prescribing in ambulatory patients with exacerbations of chronic obstructive pulmonary disease? Expert Rev Respir Med. 2020 Jun; doi:10.1080/17476348.2020.1776611. Epub 2020 Jun 04. PMID:32476530. IF: 2,725.

Llor C, Molero JM, Moragas A, Cordoba G, Bjerrum L. Use of point-of-care tests and antibiotic prescribing in sore throat and lower respiratory infections by general practitioners. Enferm. Infecc. Microbiol. Clin. 2020 Jan; 38(1):21-24. doi:10.1016/j.eimc.2019.02.005. Epub 2019 Apr 10. PMID:30981454. IF: 1,654.

Llor C, Moragas A, Vevatne K. Dual Antibiotic Therapy for Outpatient Management of Community-acquired Pneumonia?. Arch Bronconeumol. 2020 11; 56(11):765-766. doi:10.1016/j.arbres.2020.05.016. Epub 2020 Jun 24. PMID:32591142. IF: 4,957.

Medina-Perucha L, García-Sangenís A, Moragas A, Gálvez-Hernández P, Cots JM, Lanau-Roig A, Borràs A, Amo I, Monfà R, Llor C, Berenguera A. Autonomy, power dynamics and antibiotic use in primary healthcare: A qualitative study. PLoS One. 2020 ; 15(12):e0244432. doi:10.1371/journal.pone.0244432. Epub 2020 Dec 18. PMID:33338078. IF: 2,740.

Molero JM, Cordoba G, López-Valcárcel BG, Moragas A, Losa JE, Llor C. Long-term impact of an intervention on rapid antigen detection tests in acute pharyngitis. Aten Primaria. 2020 11; 52(9):637-644. doi:10.1016/j.aprim.2020.02.016. Epub 2020 May 29. pmc:PMC7713413. PMID:32482364. IF: 1,087.

ooke J, Llor C, Hopstaken R, Dryden M, Butler C. Respiratory tract infections (RTIs) in primary care: narrative review of C reactive protein (CRP) point-of-care testing (POCT) and antibacterial use in patients who present with symptoms of RTI. BMJ Open Respir Res. 2020 09; 7(1). doi:10.1136/bmjresp-2020-000624. pmc:PMC7476490. PMID:32895246.

Phillips R, Stanton H, Singh-Mehta A, Gillespie D, Bates J, Gal M, Thomas-Jones E, Lowe R, Hood K, Llor C, Melbye H, Cals J, White P, Butler C, Francis N. C-reactive protein-guided antibiotic prescribing for COPD exacerbations: a qualitative evaluation. Br J Gen Pract. 2020 07; 70(696):e505-e513. doi:10.3399/bjgp20X709865. Epub 2020 Jun 25. pmc:PMC7239040. PMID:32424045. IF: 4,190.




Researchers with PhD


Total number of projects in which group members have participated


Total number of projects in which the PI of the project has belonged to the group


Total Funding

526.305 €

Scientific publications in indexed journals


Total Impact factor


Nº of articles in Q1 journals




Nº of articles in Q2 journals




Anar a l'inici