GRIP

Infections in Primary Care Research Group

The primary objective of the group is to define a policy of antibiotics in primary care, in order to achieve a more reasoned prescription of antibiotics in infectious diseases in primary care, identifying the subgroups of patients who really need them . Other objectives are the microbiological aspects of the most prevalent community germs, to diagnose precisely the different infectious processes with the help of rapid diagnostic methods, to better identify whether the aetiology is bacterial or viral and to better understand the level of resistances of common microorganisms. The group is made up of family doctors who work in different lines of research for infectious diseases in primary care. It is planned in the future to also have professionals in the field of microbiology, pneumology, nursing staff and statisticians. We have collaborations with: hospitals (Vall d'Hebron Hospital in Barcelona and Joan XXIII Hospital in Tarragona), universities (University of Barcelona, Autonomous University of Barcelona, Rovira i Virgili University, University of Cardiff, University of Oxford and University of Copenhagen) and scientific societies (camfic, semFYC and WONCA). This group includes GPs that investigate various aspects of infectious diseases in primary care, together with other professionals such as specialists in respiratory diseases, nurses and statisticians.

The group participates in the following projects

PI: Llor Vilà, Carles. Efectividad clínica y erradicación bacteriológica de 4 pautas antibióticas cortas en infecciones urinarias en mujeres adultas. estudio SCOUT. Funding: Instituto de Salud Carlos III. Duration: 2021 - 2024

PI: Llor Vilà, Carles. Community acquired acute respiratory tract infection (CA-ARTI) in community care in Europe: point prevalence audit study (PPAS) of presentation and management. Funding: University of Oxford. Duration: 2019 - 2024

PI: Llor Vilà, Carles. Health Alliance for Prudent Prescription and Yield of Antibiotics in a Patient-centred Perspective. Funding: European Commission. Duration: 2021 - 2023

PI: Llor Vilà, Carles. Platform randomised controlled trial of point of care diagnostics for enhancing the quality of antibiotic prescribing for community acquired acute respiratory tract infection in ambulatory care in Europe (PRUDENCE). Funding: University of Oxford. Duration: 2021 - 2022

PI: Llor Vilà, Carles. Effectiveness and cost-effectiveness of Improving clinicians' diagnostic and communication Skills on Antibiotic prescribing Appropriateness in patients with acute Cough in primary care in CATalonia. Funding: Fundacio La Marato de TV3. Duration: 2019 - 2022

PI: Llor Vilà, Carles. Intervention Study - Effectiveness and cost-effectiveness of Improving clinicians' diagnostic and communication Skills on Antibiotic prescribing Appropriateness in patients with acute Cough in primary care in CATalonia. Funding: ICS - Institut Català de la Salut. Duration: 2019 - 2022

PI: Llor Vilà, Carles. Efectividad del tratamiento antitusígeno, anticolinérgico y miel versus práctica habitual en adultos con bronquitis aguda no complicada. Funding: Instituto de Salud Carlos III. Duration: 2018 - 2022

The group participates in the following publications

Baena-Díez JM, Gonzalez-Casafont I, Cordeiro-Coelho S, Fernández-González S, Rodríguez-Jorge M, Pérez-Torres CUF, Larrañaga-Cabrera A, García-Lareo M, de la Arada-Acebes A, Martín-Jiménez E, Pérez-Orcero A, Hernández-Ibáñez R, Gonzalo-Voltas A, Bermúdez-Chillida N, Simón-Muela C, Del Carlo G, Bayona-Faro C, Rey-Reñones C, Aguilar-Palacio I, Grau M. Effectiveness of Telephone Monitoring in Primary Care to Detect Pneumonia and Associated Risk Factors in Patients with SARS-CoV-2. Healthcare (Basel). 2021 Nov; 9(11). doi:10.3390/healthcare9111548. Epub 2021 Nov 13. pmc:PMC8621826. PMID:34828594. IF: 1,916.

Baena-Díez JM, Pinnegar HP, Paredes-Millán MK, Plaza-Cerrato L, Palomino-Español E, Cots JM. Incidence of SARS-CoV-2 infection in close contacs. Telephone follow-up in Primary Care. Med Clin (Engl Ed). 2021 May; 156(9):444-446. doi:10.1016/j.medcle.2020.11.018. Epub 2021 Mar 19. pmc:PMC7972667. PMID:33763599. IF: .

Garcia-Sangenís A, Morros R, Aguilar-Sánchez M, Medina-Perucha L, Leiva A, Ripoll J, Martínez-Pecharromán M, Bartolomé-Moreno CB, Magallon Botaya R, Marín-Cañada J, Molero JM, Moragas A, Troncoso A, Monfà R, Llor C; SCOUT Study Group. Clinical effectiveness and bacteriological eradication of three different Short-COurse antibiotic regimens and single-dose fosfomycin for uncomplicated lower Urinary Tract infections in adult women (SCOUT study): study protocol for a randomised clinical trial. BMJ Open. 2021 11; 11(11):e055898. doi:10.1136/bmjopen-2021-055898. Epub 2021 Nov 25. pmc:PMC8627395. PMID:34824124. IF: 2,692.

Llor C, Moragas A, Bayona C, Cots JM, Hernández S, Calviño O, Rodríguez M, Miravitlles M. Efficacy and safety of discontinuing antibiotic treatment for uncomplicated respiratory tract infections when deemed unnecessary. A multicentre, randomized clinical trial in primary care. Clin Microbiol Infect. 2021 Aug; doi:10.1016/j.cmi.2021.07.035. Epub 2021 Aug 04. PMID:34363942. IF: 8,067.

Llor C, Ouchi D, Giner-Soriano M, García-Sangenís A, Bjerrum L, Morros R. Correlation between Previous Antibiotic Exposure and COVID-19 Severity. A Population-Based Cohort Study. Antibiotics (Basel). 2021 Nov; 10(11). doi:10.3390/antibiotics10111364. Epub 2021 Nov 08. pmc:PMC8615228. PMID:34827302. IF: 4,639.

Llor C. Effectiveness of Adding a Mask Recommendation to Other Public Health Measures. Ann Intern Med. 2021 08; 174(8):1194. doi:10.7326/L21-0399. PMID:34399078. IF: 25,391.

Medina-Perucha L, Gálvez-Hernández P, García-Sangenís A, Moragas A, Cots JM, Lanau-Roig A, Borrás A, Amo I, Barragán N, Monfá R, Llor C, Berenguera A. A Co-Design Process to Elaborate Educational Materials to Promote Appropriate Use of Antibiotics for Acute Lower Respiratory Tract Infections in Primary Healthcare in Catalonia (Spain). Patient Prefer Adherence. 2021 ; 15:543-548. doi:10.2147/PPA.S297581. Epub 2021 Mar 08. pmc:PMC7954036. PMID:33727799. IF: 2,711.

Moragas A, Garcia-Sangenís A, Prats Escudero A, Bayona Faro C, Hernández Ibáñez R, Brotons C, Vilella T, Puig M, Freixedas Casaponsa R, Cobo Guerrero S, Pera H, van der Velden AW, Butler CC, Llor C. [Prevalence of microbiologically-confirmed influenza in patients with influenza-like illness in primary care and clinical and epidemiological characteristics]. Rev Esp Quimioter. 2021 Oct; 34(5):468-475. doi:10.37201/req/032.2021. Epub 2021 Jun 13. Spanish. PMID:34118801. IF: 1,553.

Ouchi D, García-Sangenís A, Moragas A, van der Velden AW, Verheij TJ, Butler CC, Bongard E, Coenen S, Cook J, Francis NA, Godycki-Cwirko M, Lundgren PT, Lionis C, Radzeviciene Jurgute R, Chlabicz S, De Sutter A, Bucher HC, Seifert B, Kovács B, de Paor M, Sundvall PD, Aabenhus R, Harbin NJ, Ieven G, Goossens H, Lindbæk M, Bjerrum L, Llor C. Clinical prediction of laboratory-confirmed influenza in adults with influenza-like illness in primary care. A randomized controlled trial secondary analysis in 15 European countries. Fam Pract. 2021 Oct; doi:10.1093/fampra/cmab122. Epub 2021 Oct 06. PMID:34611715. IF: 2,267.

Pla-Pagà L, Pedret A, Valls RM, Calderón-Pérez L, Llauradó E, Companys J, Martín-Luján F, Moragas A, Canela N, Puiggròs F, Caimari A, Del Bas JM, Arola L, Solà R, Mayneris-Perxachs J. Effects of Hesperidin Consumption on the Cardiovascular System in Pre- and Stage 1 Hypertensive Subjects: Targeted and Non-Targeted Metabolomic Approaches (CITRUS Study). Mol Nutr Food Res. 2021 09; 65(17):e2001175. doi:10.1002/mnfr.202001175. Epub 2021 Aug 02. PMID:34272817. IF: 5,914.

Sisó-Almirall A, Brito-Zerón P, Conangla Ferrín L, Kostov B, Moragas Moreno A, Mestres J, Sellarès J, Galindo G, Morera R, Basora J, Trilla A, Ramos-Casals M, On Behalf Of The CAMFiC Long Covid-Study Group. Long Covid-19: Proposed Primary Care Clinical Guidelines for Diagnosis and Disease Management. Int J Environ Res Public Health. 2021 04; 18(8). doi:10.3390/ijerph18084350. Epub 2021 Apr 20. pmc:PMC8073248. PMID:33923972. IF: 2,849.

Valls RM, Pedret A, Calderón-Pérez L, Llauradó E, Pla-Pagà L, Companys J, Moragas A, Martín-Luján F, Ortega Y, Giralt M, Romeu M, Rubió L, Mayneris-Perxachs J, Canela N, Puiggrós F, Caimari A, Del Bas JM, Arola L, Solà R. Effects of hesperidin in orange juice on blood and pulse pressures in mildly hypertensive individuals: a randomized controlled trial?(Citrus study). Eur J Nutr. 2021 Apr; 60(3):1277-1288. doi:10.1007/s00394-020-02279-0. Epub 2020 Jul 13. pmc:PMC7987641. PMID:32661681. IF: 5,614.

Indicators

Indicator	2021
Researchers with PhD	15
Total number of projects in which group members have participated	8
Total number of projects in which the PI of the project has belonged to the group	8
Total Funding	1.040.813,87 €
Scientific publications in indexed journals	11
Total Impact factor	63,61
Nº of articles in Q1 journals	4
Q1 IF	44,986
Nº of articles in Q2 journals	3
Q2 IF	10,042

Members

PI: Llor Vilà, Carles

Bayona Faro, Carolina

Boada Valmaseda, Albert

Cots Yago, Josep M.

Hernández Anadón, Silvia

López Plana, Ana

Moragas Moreno, Ana

Research Lines

Rational use of antibiotics in respiratory tract infections. To know the long-term effectiveness of a multicentric strategy in the use of antibiotics in respiratory infections. To know the effectiveness of an intervention, Infections of the lower respiratory tract: better understanding of subgroups of patients who can benefit from antibiotic treatment and better understanding of the effectiveness of symptomatic treatments in patients with cough., Otitis externa. To know the effectiveness of topical antiseptic treatment compared to oral antibiotic therapy in the resolution of acute otorrea, Acute pharyngitis: knowing the etiology of pharyngitis in adults based on microbiological analysis, effectiveness of the antibiotic treatment, knowing which of the diagnostic strategies help to make a more reasoned use of antibiotics, Urinary tract infections: role of rapid diagnostic methods in the rational use of antibiotics in these infections. Distinguishing urinary tract infections better from urethritis at primary care.

Total funding

1.040.813,87 €

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