GRIP

Infections in Primary Care Research Group

The primary objective of the group is to define a policy of antibiotics in primary care, in order to achieve a more reasoned prescription of antibiotics in infectious diseases in primary care, identifying the subgroups of patients who really need them . Other objectives are the microbiological aspects of the most prevalent community germs, to diagnose precisely the different infectious processes with the help of rapid diagnostic methods, to better identify whether the aetiology is bacterial or viral and to better understand the level of resistances of common microorganisms. The group is made up of family doctors who work in different lines of research for infectious diseases in primary care. It is planned in the future to also have professionals in the field of microbiology, pneumology, nursing staff and statisticians. We have collaborations with: hospitals (Vall d'Hebron Hospital in Barcelona and Joan XXIII Hospital in Tarragona), universities (University of Barcelona, Autonomous University of Barcelona, Rovira i Virgili University, University of Cardiff, University of Oxford and University of Copenhagen) and scientific societies (Camfic, semFYC and WONCA). This group includes GPs that investigate various aspects of infectious diseases in primary care, together with other professionals such as specialists in respiratory diseases, nurses and statisticians.

The group participates in the following projects

PI: Llor Vilà, Carles. Efectividad del tratamiento antitusígeno, anticolinérgico y miel versus práctica habitual en adultos con bronquitis aguda no complicada. Funding: Instituto de Salud Carlos III. Duration: 2018 - 2020

PI: Llor Vilà, Carles. Effectiveness and cost-effectiveness of Improving clinicians' diagnostic and communication Skills on Antibiotic prescribing Appropriateness in patients with acute Cough in primary care in CATalonia. Funding: Fundacio La Marato de TV3. Duration: 2018 - 2020

PI: Llor Vilà, Carles. Regulating Resistance, Resisting Regulation: New regimes to tackle drug resistant infections in European and Asian healthcare systems. Funding: ICS - Institut Català de la Salut. Duration: 2018 - 2019

PI: Llor Vilà, Carles. Estudio europeo multicéntrico de enfermedades infecciosas respiratorias: Infecciones Respiratorias Agudas en Adultos. Estudi MERMAIDS. Funding: University of Oxford. Duration: 2017 - 2019

PI: Llor Vilà, Carles. Estudi exploratori de les visites per tos aguda i maneig efectuat a les consultes d'atenció primària a Barcelona. Funding: ICS - Institut Català de la Salut. Duration: 2018

PI: Llor Vilà, Carles. ¿Antivirales para el tratamiento de enfermedades con síntomas gripales? Ensayo clínico aleatorio de la efectividad clínica y económica en Atención Primaria (ALIC4E). Funding: University of Oxford. Duration: 2016 - 2018

The group participates in the following publications

Boada A, Pons-Vigués M, Real J, Grenzner E, Bolíbar B, Llor C. Previous antibiotic exposure and antibiotic resistance of commensal Staphylococcus aureus in Spanish primary care. Eur J Gen Pract. 2018;24(1):125-130. PMID:29542385. IF: 1,274.

Bobé F, Buil ME, Hernández S, Calviño O. Vejiga hiperactiva. Actualitzaciones. FMC. Formación Médica Continuada en Atención Primaria. 2018;25(4):208-222.

Bobé F, Buil ME, Solís R, Moragas A. Retención de orina en la mujer. FMC. Formación Médica Continuada en Atención Primaria. 2018;25(8):477-482.

Bongard E, van der Velden AW, Cook J, Saville B, Beutels P, Munck Aabenhus R, Brugman C, Chlabicz S, Coenen S, Colliers A, Davies M, De Paor M, De Sutter A, Francis NA, Glinz D, Godycki-wirko M, Goossens H, Holmes J, Ieven M, de Jong M, Lindbaek M, Little P, Martinón-Torres F,Moragas A. Pauer J, Pfeiferová M, Radzeviciene-Jurgute R, Sundvall PD, Torres A, Touboul P, Varthalis D, Verheij T, Butler CC. Antivirals for influenza-Like Illness? A randomised Controlled trial Antivirals for influenza- Like Illuness? A randomised Controlled trial of Clinical and Cost effectiveness in primary CarE (ALIC (4): THE alic (4) E protocol. BMJ. 2018;12;8(7):e021032. PMID:30002007. IF: 23,295.

Guinovart MC, Figueras A, Llor C. Selling antimicrobials without prescription - Far beyond an administrative problem. Enfermedades infecciosas y microbiologia clinica. 2018 05; 36(5):290-292. doi:10.1016/j.eimc.2016.10.006. Epub 2016 Nov 17. PMID:27866752. IF: 1,714.

Llor C, Bjerrum L, Molero JM, Moragas A, González López-Valcárcel B, Monedero MJ, Gómez M, Cid M, Alcántara JD, Cots JM, Ribas JM, Garcia G, Ortega J, Pineda V, Guerra G, Munuera S. Long-term effect of a practice-based intervention (HAPPY AUDIT) aimed at reducing antibiotic prescribing in patients with respiratory tract infections. J Antimicrob Chemother. 2018;1;73(8):2215-2222. PMID:29718420. IF: 5,071.

Llor C, Bjerrum L. Short courses of penicillin for streptococcal pharyngitis are not supported by the evidence. Family practice. 2018 Mar; 35(2):228-229. doi:10.1093/fampra/cmx126. PMID:29244068. IF: 1,804.

Llor C, Boada A, Pons-Vigués M, Grenzner E, Juvé R, Almeda J. Antibiotic susceptibility of Staphylococcus aureus and Streptococcus pneumoniae in healthy carrier individuals in primary care in Barcelona area. Aten Primaria. 2018;50(1):44-52. PMID:28413102. IF: 1,042.

Moragas A, Hernández S, Cortiles S, Llor C. Clinical utility of a white blood cell and differential count point_of_care teast and agreenebt with routine laboratory. Butlletí de la CAMFIC. 2018;36:4.

Pedret A, Valls RM, Calderon- Pérez L, Llauradó E, Companys J, Pla-Pagà L, Moragas A, Martín F, Ortega Y, Giralt M, Caimari A, Chenoll E, Genovés S, Martorell P, Codoñer FM, ramon D, Arola L, Solà R. Effects of daily consumption of the probiotic Bifidobacterium animalis subsp. lactis CECT 8145 on anthropometric adiposity biomarkers in abdominally obese subjects: a randomized controlled trial. Int J Obes (Lond). 2018;doi:10.1038:/s41366-018-0220-0. PMID:30262813. IF: 5,487.

Indicators

Indicator	2018
Researchers with PhD	12
Total number of projects in which group members have participated	6
Total number of projects in which the PI of the project has belonged to the group	6
Total Funding	509.821,00€
Scientific publications in indexed journals	7
Total Impact factor	39,69
Nº of articles in Q1 journals	3
Q1 IF	33,853
Nº of articles in Q2 journals	1
Q2 IF	1,804

Members

PI: Llor Vilà, Carles

Bayona Faro, Carolina

Boada Valmaseda, Albert

Cots Yago, Josep M.

Hernández Anadón, Silvia

López Plana, Ana

Moragas Moreno, Ana

Research Lines

Rational use of antibiotics in respiratory tract infections. To know the long-term effectiveness of a multicentric strategy in the use of antibiotics in respiratory infections. To know the effectiveness of an intervention, Infections of the lower respiratory tract: better understanding of subgroups of patients who can benefit from antibiotic treatment and better understanding of the effectiveness of symptomatic treatments in patients with cough, Otitis externa. To know the effectiveness of topical antiseptic treatment compared to oral antibiotic therapy in the resolution of acute otorrea, Acute pharyngitis: knowing the etiology of pharyngitis in adults based on microbiological analysis, effectiveness of the antibiotic treatment, knowing which of the diagnostic strategies help to make a more reasoned use of antibiotics, Urinary tract infections: role of rapid diagnostic methods in the rational use of antibiotics in these infections. Distinguishing urinary tract infections better from urethritis at primary care.

Research career Award

ICS award for Dr. Carles Llor research career during the 10th ICS Research Day and the 11th IDIAPJGol Research Day, which was held in CosmoCaixa (Barcelona), jointly organized by both institutes.

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