GRIMTra

Research Group on the Impact of Chronic Diseases and Their Trajectories

The research group primarily focuses on investigating the associations between chronic diseases, a concept known as multimorbidity (MM). Disease development relies on numerous genetic factors as well as external factors that influence gene expression, such as environmental conditions, social status, and lifestyle. The study of MM across individuals' lifespans and the duration within each MM category is commonly referred to as MM trajectories or disease trajectories. Utilizing artificial intelligence and bioinformatics, the group aims to integrate diverse data types through algorithms to personalize health recommendations more effectively. Consequently, the group's objectives include the identification of MM clusters, determination of their trajectories, and analysis of the influencing factors. These objectives will be pursued by leveraging electronic medical records, genetic and environmental data, lifestyle and social information, using advanced informatics techniques within population-based cohorts connected to electronic health records.

Grup projects

R+D+I PROJECTS FUNDED IN COMPETITIVE CALLS FROM ADMINISTRATIONS OR PUBLIC AND PRIVATE ENTITIES

  • -    Validació amb cohorts externes d'un model predictiu longitudinal entrenat amb dades de pacients crònics - SIDIAP. (MV22/00026). Instituto de Salud Carlos III. 2022-2023. IP: Lucía Amalia Carrasco Ribelles. 

  • -    Pla estrategic de recerca Grup ARTPER. (SENIOR-19/1). ICS - Institut Català de la Salut. 2020-2023. IP: Mª Teresa Alzamora Sas. 

  • -    Multimorbidity and Frailty Trajectories and Explainable Prediction Models for Health-related Outcomes Using Longitudinal Electronic Health Records of the Ageing Catalan Population. Institut d'Investigació en Atenció Primària Jordi Gol i Gurina (IDIAPJGol). IP: Lucía Amalia Carrasco Ribelles. 

  • -    La microcirculació retiniana com a factor de risc cardiovascular. ICS - Institut Català de la Salut. 2023IP: Antoni Heras Tébar. 

  • -    Kinetics of humoral immune response over 17 months of covid 19 pandemic in a large cohort of healthcare workers in spain: the PROHEPIC 19 Study. Col.legi Oficial de Metges de Barcelona; Fundació Academia Ciencies Mediques de Catalunya I de Balears (L'Acadèmia). 2023IP: Concepció Violán Fors. 

  • -    Grup d'estudi de Recerca en Malalties Hepàtiques en Atenció Primària (GRemHAp). (INTENS-19/9). ICS - Institut Català de la Salut. 2020-2023. IP: Carmen Expósito Martínez. 

  • -    FRAGICAP. (2015/001). Institut d'Investigació en Atenció Primària Jordi Gol i Gurina (IDIAPJGol). 2015IP: Francesc Orfila Pernas. 

  • -    Estudi del fetge gras no alcohòlic i les seves comorbiditats associades a Catalunya. Fundació Academia Ciencies Mediques de Catalunya I de Balears (L'Acadèmia). 2023IP: Alba Martínez Escudé. 

  • -    Construcción y validación de un Score predictivo de riesgo de institucionalización, ingresos hospitalarios y mortalidad, en mayores de 65 años con multimorbilidad y fragilidad. (FI20/00040). Instituto de Salud Carlos III. 2020-2023. IP: Lucía Amalia Carrasco Ribelles. 

  • -    Consolidació Recerca en Malalties Hepàtiques a la DAP Metropolitana Nord. Grup GRemHAp. ICS - Institut Català de la Salut. 2022-2024. IP: Alba Martínez Escudé. 

  • -    Consolidació Recerca en malalties Hepàtiques a la DAP Metropolitana Nord. Grup GRemHAp. (INTENS-19/6). ICS - Institut Català de la Salut. 2020-2023. IP: Alba Martínez Escudé. 

  • -    Anàlisis de la microcirculació retiniana com a factor de risc cardiovascular en la cohort ARTPER. Estudi Retino-ARTPER. (INTENS-19/11). ICS - Institut Català de la Salut. 2020-2023. IP: Antoni Heras Tébar.

CONTRACTS, AGREEMENTS OR NON-COMPETITIVE R+D+I PROJECTS WITH ADMINISTRATIONS OR PUBLIC OR PRIVATE ENTITIES.

  • TADIA_MED. Universitat Politècnica de Catalunya (UPC). 2020-2024. IP: Concepció Violán Fors.

CLINICAL STUDIES

  • Terapia de ejercicio supervisado en sujetos con arteriopatía periférica sintomática. (PI20/00129). Instituto de Salud Carlos III. 2020-2024. IP: Pere Torán Monserrat,Mª Teresa Alzamora Sas.

  • Professionals, health care workers healthy and infected with SARS-CoV2 long-term incidence, reinfection, serological protection and impact of vaccination: The ProHEpiC-19+ Cohort study. ICS - Institut Català de la Salut. 2021 IP: Concepció Violán Fors.

  • Niveles de TSH como factor de riesgo independiente del HGNA y fibrosis hepática en la población general. Col.legi Oficial de Metges de Barcelona. 2022-2025. IP: Carmen Expósito Martínez.

  • Multimorbilidad en el Sistema Nacional de Salud: Caracterización poblacional e impacto de sus patrones y trayectorias en personas mayores (Proyecto MM-SNS). (PI22/01398). Instituto de Salud Carlos III. 2022-2025. IP: Concepció Violán Fors.

  • Infecció post-vacunal per-SARS-CoV2: Estudi de cohort per la caracterització de la resposta immune i desenvolupament d'un model de predicció per establir criteris de revacunació a Catalunya (BreakCOVID). (SLT021/21/000038). Generalitat Catalunya.Departament de Salut. 2022 IP: Concepció Violán Fors.

  • Incidència d'esdeveniments cardiovasculars en pacients COVID-19 a Catalunya. Estudi poblacional amb base de dades SIDIAP. Institut d'Investigació en Atenció Primària Jordi Gol i Gurina (IDIAPJGol). 2021-2023. IP: Mª Teresa Alzamora Sas.

  • IMMunE Response against SARS-CoV-2 an ageIng community pOpulation in Northern of Metropolitana area of Barcelona (IMMERSION). ICS - Institut Català de la Salut. 2021-2023. IP: Concepció Violán Fors.

  • Genetic Evaluation of Multimorbidity towards INdividualisation of Interventions. National Institute for Health Research. 2020-2023. IP: Concepció Violán Fors.

  • Estudio de asociación entre antihistamínicos y supervivencia del cáncer (Antihistamines to improve cancer care). ICS - Institut Català de la Salut. 2021-2023. IP: Concepció Violán Fors.

  • Estudi de l'impacte de la pandèmia per Sars-CoV-2 en les cobertures vacunals a Catalunya. ICS - Institut Català de la Salut. 2022 IP: Edurne Zabaleta del Olmo.

  • Epidemiología clínica de la enfermedad por hígado graso no alcohólico en niños y adolescentes (LIVER KIDS). Instituto de Salud Carlos III. 2021-2023. IP: Carmen Expósito Martínez.

  • Epidemiología clínica de la enfermedad del hígado graso no alcohólico en niños y adolescentes. Estudio LiverKids. (SLT021/21/000047). Generalitat Catalunya.Departament de Salut. 2022 IP: Carmen Expósito Martínez.

  • Construcción y validación de un Score predictivo de riesgo de institucionalización, ingresos hospitalarios y mortalidad, en mayores de 65 años con multimorbilidad y fragilidad - Validación SNAC-K (OMOP). 2023 IP: Concepció Violán Fors.

  • Construcción y validación de un Score predictivo de riesgo de institucionalización, ingresos hospitalarios y mortalidad, en mayores de 65 años con multimorbilidad y fragilidad. (PI19/00535). Instituto de Salud Carlos III. 2019-2023. IP: Concepció Violán Fors.

  • Comorbidity prevalence between HIV positive and HIV negative patients over 40 years of age. ICS - Institut Català de la Salut. 2021 IP: Concepció Violán Fors.

  • Avaluació de la Fragilitat Física, Cognitiva i Social. Interrelacions, factors associats i factors pronòstic d'institucionalització i mort. ICS - Institut Català de la Salut. 2022 IP: Francesc Orfila Pernas.

  • Adaptació i validació de la "Practice Environment Scale of the Nursing Work Index" al context organitzatiu dels equips d'Atenció Primària de salut i penitenciària de l'Institut Català de la Salut. 2022 IP: Edurne Zabaleta del Olmo.

Group publications

JOURNAL PUBLICATIONS

  • Sanchez Durán MA, Maiz N, Liutsko L, Bielsa Pascual J, García Sierra R, Zientalska AM et al. Universal screening programme for cytomegalovirus infection in the first trimester of pregnancy: study protocol for an observational multicentre study in the area of Barcelona (CITEMB study). BMJ Open. 2023;13(7): PMID:37474185.

  • Collatuzzo G, De Palma G, Violante FS, Porru S, Filon FL, Fabianova E et al. Temporal trends of COVID-19 antibodies in vaccinated healthcare workers undergoing repeated serological sampling: an individual-level analysis within 13 months in the ORCHESTRA cohort (vol 13, 1079884, 2023). Front. Immunol. 2023;141197923-1197923. PMID:37122701.

  • Collatuzzo G, De Palma G, Violante FS, Porru S, Filon FL, Fabianova E et al. Temporal trends of COVID-19 antibodies in vaccinated healthcare workers undergoing repeated serological sampling: An individual-level analysis within 13 months in the ORCHESTRA cohort. Front. Immunol. 2023;131079884-1079884. PMID:36713452.

  • Torán P, Montesinos S, Pachon Camacho A, Diez Fadrique G, Ruiz Rojano I, Arteaga I et al. Risky Alcohol Consumption in the Elderly: Screening and Brief Intervention from Primary Care. The ALANE Study, a Randomized Clinical Trial. Beverages. 2023;9(4):

  • Zabaleta Olmo E, Santesmases Masana R, Martín Payo R, Romero Collado A, Zamora Sánchez JJ, Urpí Fernández AM et al. Research on missed nursing care during the COVID-19 pandemic: A scoping review. Worldviews Evid. -Based Nurs. 2023;20(6):559-573. PMID:37743584.

  • Lejeune M, Reverte L, Sauras E, Gallardo N, Bosch R, Roso A et al. Prognostic Implications of the Residual Tumor Microenvironment after Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer Patients without Pathological Complete Response. Cancers. 2023;15(3): PMID:36765559.

  • Carrasco Ribelles LA, Llanes Jurado J, Gallego Moll C, Cabrera Bean M, Monteagudo Zaragoza M, Violán C et al. Prediction models using artificial intelligence and longitudinal data from electronic health records: a systematic methodological review. J. Am. Med. Informatics Assoc. 2023;30(12):2072-2082. PMID:37659105.

  • de Homdedeu M, Sanchez Moral L, Violan C, Ràfols N, Ouchi D, Martín B et al. Mycobacterium manresensis induces trained immunity in vitro. iScience. 2023;26(6):106873-106873. PMID:37250788.

  • Valletta M, Vetrano DL, Xia X, Rizzuto D, Roso Llorach A, Calderón Larrañaga A et al. Multimorbidity patterns and 18-year transitions from normal cognition to dementia and death: A population-based study. J. Intern. Med. (GBR). 2023;294(3):326-335. PMID:37306092.

  • Violán C, Carrasco Ribelles LA, Collatuzzo G, Ditano G, Abedini M, Janke C et al. Multimorbidity and Serological Response to SARS-CoV-2 Nine Months after 1st Vaccine Dose: European Cohort of Healthcare Workers-Orchestra Project. Vaccines. 2023;11(8): PMID:37631908.

  • Lejeune M, Reverté L, Gallardo N, Sauras E, Bosch R, Mata D et al. Matrix Metalloproteinase-9 Expression Is Associated with the Absence of Response to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer Patients. Int. J. Mol. Sci. 2023;24(14): PMID:37511057.

  • Dimitriadis SI, Castells Sánchez A, Roig Coll F, Dacosta Aguayo R, Lamonja Vicente N, Torán Monserrat P et al. Intrinsic functional brain connectivity changes following aerobic exercise, computerized cognitive training, and their combination in physically inactive healthy late-middle-aged adults: the Projecte Moviment. GeroScience. 2023;46(1):573-596. PMID:37872293.

  • Porru S, Monaco MGL, Spiteri G, Carta A, Caliskan G, Violán C et al. Incidence and Determinants of Symptomatic and Asymptomatic SARS-CoV-2 Breakthrough Infections After Booster Dose in a Large European Multicentric Cohort of Health Workers-ORCHESTRA Project. J. Epidemiol. Global Health. 2023;13(3):577-588. PMID:37480426.

  • Montserrat Capdevila J, Fornells Barberà I, Roso Llorach A, Olivares Sanzo P, Romero Gracia A, Ichart JX. Impacto de la COVID-19 en la salud mental de la población: estudio en atención primaria. Aten. Prim. 2024;56(3):102813-102813. PMID:38039619.

  • Martinez Marcos M, Zabaleta Olmo E, Gomez Duran EL, Rene A, Cabezas Pena C. Impact of the COVID-19 lockdown on routine childhood vaccination coverage rates in Catalonia (Spain): a public health register-based study. Public Health. 2023;21868-74. PMID:36972643.

  • Alcañiz M, Giglioli I, Carrasco Ribelles LA, Minissi ME, López CG, Semin GR. How priming with body odors affects decision speeds in consumer behavior. Sci Rep. 2023;13(1):609-609. PMID:36635353.

  • Megido MJ, Celdran M, Ferrer A, Roca M, Pujol Ribera E, Zabaleta Olmo E. Grandchildren of grandparents with Alzheimer's disease: Exploratory study of the impact of the disease on their relationships. Dementia. 2023;22(4):838-853. PMID:36916529.

  • Troncoso Mariño A, Lestón Vázquez M, Gallardo Borge S, Del Val Garcia JL, Amado Guirado E, Violán C. Fracture risk after deprescription of bisphosphonates: Application of real-world data in primary care. Aten. Prim. 2023;55(7):102651-102651. PMID:37187104.

  • Serra Burriel M, Juanola A, Serra Burriel F, Thiele M, Graupera I, Pose E et al. Development, validation, and prognostic evaluation of a risk score for long-term liver-related outcomes in the general population: a multicohort study. Lancet. 2023;402(10406):988-996. PMID:37572680.

  • Leomanni L, Collatuzzo G, Sansone E, Sala E, De Palma G, Porru S et al. Determinants of Anti-S Immune Response at 12 Months after SARS-CoV-2 Vaccination in a Multicentric European Cohort of Healthcare Workers-ORCHESTRA Project. Vaccines. 2023;11(10): PMID:37896931.

  • Graupera I, Thiele M, Ma AT, Serra Burriel M, Pich J, Fabrellas N et al. Correction: LiverScreen project: study protocol for screening for liver fibrosis in the general population in European countries. BMC Public Health. 2023;23(1):923-923. PMID:37217864.

  • Carrasco Ribelles LA, Cabrera Bean M, Danes Castells M, Zabaleta Olmo E, Roso Llorach A, Violan C. Contribution of Frailty to Multimorbidity Patterns and Trajectories: Longitudinal Dynamic Cohort Study of Aging People. JMIR Publ. Heal. Surveil. 2023;9PMID:37368462.

  • Chacón C, Arteaga I, Martínez Escudé A, Rojano IR, Lamonja Vicente N, Caballeria L et al. Clinical epidemiology of non-alcoholic fatty liver disease in children and adolescents. The LiverKids: Study protocol. PLoS One. 2023;18(10): PMID:37831682.

  • Roig Coll F, Castells Sánchez A, Monté Rubio G, Dacosta Aguayo R, Lamonja Vicente N, Toran Monserrat P et al. Changes in cardiovascular health and white matter integrity with aerobic exercise, cognitive and combined training in physically inactive healthy late-middle-aged adults: the "Projecte Moviment" randomized controlled trial. Eur. J. Appl. Physiol. 2023;124(3):909-924. PMID:37768344.

  • León Gómez BB, Moreno Gabriel E, Carrasco Ribelles LA, Fors CV, Liutsko L. Challenges and obstacles of artificial intelligence in health research. Gac. Sanit. 2023;37102315-102315. PMID:37418947.

  • Heumann M, Röhnsch G, Zabaleta Olmo E, Toso BRGD, Giovanella L, Hämel K. Barriers to and enablers of the promotion of patient and family participation in primary healthcare nursing in Brazil, Germany and Spain: A qualitative study. Health Expect. 2023;26(6):2396-2408. PMID:37565592.

  • Julian MT, Ballesta S, Pera G, de Oca A, Soldevila B, Caballeria L et al. Abdominal obesity and dsyglycemia are risk factors for liver fibrosis progression in NAFLD subjects: A population-based study. Front. Endocrinol. 2023;131051958-1051958. PMID:36714592.

  • Gomez I, Motrico E, Moreno Peral P, Casajuana Closas M, Lopez Jimenez T, Zabaleta Olmo E et al. A multiple health behaviour change intervention to prevent depression: A randomized controlled trial. Gen. Hosp. Psychiatry. 2023;8286-94. PMID:37001428.

PROCEEDING PAPERS

  • Abiétar DG, Aragón B, Orfila F, Almirall R. Transgender individuals' expectations and satisfaction with gender affirmation care in spain: a sequential mixed methods study. Gac. Sanit. 2023;37197-197.

  • Villesen IF, Graupera I, Pera G, Serra Burriel M, Arslanow A, Hansen JK et al. Short-term variation in transient elastography measurements when used as a population screening tool. Hepatology. 2023;781728-1729.

  • Hernández R, Hoyo J, Carol M, Nadal R, Juanola A, Soria A et al. Patients with risk factors for liver diseases associated with hepatic steatosis constitute the target population for liver fibrosis assessment in primary care. J. Hepatol. 2023;78664-665.

  • Carmona Cervelló M, León Gómez BB, Lamonja Vicente N, Dacosta Aguayo R, Roger AA, Reynés AF et al. Identification of the impact in people with persistent COVID-19 and cognitive complaints. Gac. Sanit. 2023;37249-249.

  • Bruguera A, Díaz Y, Carrasco L, Roso Llorach A, Nomah D, Moreno Fornés S et al. Earlier and higher comorbidities in people living with hiv compared to general population in Catalonia. Gac. Sanit. 2023;3781-81.

  • Voller BA, Tata E, Gallego Moll C, Roso Llorach A, Bowden J, Masoli J et al. An atlas of genetic contributions to multimorbidity. Hum. Hered. 2023;88(SUPPL 1):63-63.

Thesis

  • Villén N(Autor). Patrons de multimorbiditat i polimediació en una cohort de població en majors de 65 anys a Catalunya. [Tesis Doctoral]. UNIVERSIDAD AUTÓNOMA DE BARCELONA. 2023.

  • Roso A(Autor). Multimorbidity patterns in two older populations from north and south Europe. [Tesis Doctoral]. Barcelona. UNIVERSIDAD AUTÓNOMA DE BARCELONA. 2023.

  • Troncoso A(Autor). Descripción y evolución problemas relacionados con la medicación en paciente anciano asociados a los patrones de multimorbilidad y polimedicación e impacto en la utilización de servicios sanitarios y mortalidad. [Tesis Doctoral]. UNIVERSIDAD DE BARCELONA. 2023.

  • Herrero C(Autor). Avaluació de l´exercici físic supervisat en persones amb arteriopatia perifèrica amb un assaig clínic aleatoritzat. [Tesis Doctoral]. UNIVERSIDAD AUTÓNOMA DE BARCELONA.

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