1. Annual report 2024
  2. Research
  3. ISV-Girona

ISV-Girona

Girona Vascular Health Research Group

The ISV research group offers a broad spectrum of expertise in both methodologies and thematic areas of primary care. The group is fully integrated into the RICAPPS network (Network for Research in Chronicity, Primary Care and Health Promotion, RICORS program) since Dr. Ramos is also the coordinator of the network. The ISV group is multidisciplinary: it includes experienced primary care physicians, epidemiologists, nurses, biologists, mathematicians, and biostatisticians (ensuring accurate and rigorous data analysis). His research focuses on three main lines of research, with which we intend to continue over the next three years.

Group projects

  • Implementation of a genetic tool to strengthen cardiovascular prevention in Primary Care (GENINCODE). 2024-2026. PI: Rafel Ramos Blanes.
  • L-WORLD IN HEALTH:Filling knowledge gaps and promoting competent primary care for Lesbians. - L-HEALTH. (101144766). European Commission. 2024-2026. IP: Anna Ponjoan Thans.
  • CARGENCORS / CARdiovascular GENetic risk score for Risk Stratification of patients positive for SARS-CoV-2 (COvid 19) virus. GENinCode Plc. 2022-2025. IP: Rafel Ramos Blanes.
  • Cardiovascular disease prevention programme based on screening for asymptomatic peripheral artery disease. [Health program for prEvention of cardiovascular disEases based on a risk screeNing strategy with Ankle-brachial index]. HELENA Study. (SLT021/21/000015). Generalitat Catalunya. 2022-2025. IP: Rafel Ramos Blanes.
  • Risk factors, cardiovascular disease and lifestyles in sexual and gender minorities: a population-based study based on electronic health records. (PI21/00508). Carlos III Health Institute. 2021-2026. PI: Mª del Mar García Gil.
  • Mendelian Randomization to assess causal genetic pathways leading to severe COVID-19. Fundació La Marató de TV3. 2021-2024. IP: Ruth Martí Lluch.
  • A longitudinal population-based study to determine whether atrial fibrillation is an independent risk factor for the development of dementia and whether the quality and type of oral anticoagulation influence this association (AF-DEMOAC study). Bellvitge Biomedical Research Institute IDIBELL. 2020-2024. PI: Anna Ponjoan Thans.
  • Level and variation of cardiovascular risk and prevention of dementia. (PI20/01239). Carlos III Health Institute. 2020-2024. PI: Anna Ponjoan Thans.
  • Stratification of Obese Phenotypes to Optimize Future Obesity Therapy (SOPHIA). (875534). Innovative Medicines Initiative (IMI). 2020-2025. IP: Rafel Ramos Blanes.
  • REVEAL Cohort. Analysis of the role of personal aptitudes as determinants of the incidence of morbidity, life styles, quality of life, use of services and mortality. (PI19/00147). Carlos III Health Institute. 2019-2024. PI: Ruth Martí Lluch.
  • Effectiveness of de-implementation strategies to promote the cessation of low-value pharmacological prescriptions in primary prevention of CVD: DE-imFAR Phase II project. Carlos III Health Institute. PI21/00025. 2022-2024. PI: Sánchez A. Inv.Col: García A, Lago FI, Parramón D.
  • The first 10-year genome-wide association study (GWAS) with population-based coronary heart disease in more than 100,000 participants to personalize cardiovascular prevention in Spain. Carlos III Health Institute. PMP22/00033. 2022-2025. PI: Marrugat J. Inv.Col: Alonso M, Ramos R.
  • Current status of social prescription in the Primary Care centres of the Catalan Institute of Health in the Girona Health Region. ICS - Catalan Institute of Health. . 2023-2025. IP: Navarro A. Inv.Col: Martí R.
  • Experiences and needs of trans* people in Primary Care. Qualitative study. IDIAP Jordi Gol. PROJ-23/12. 2024-2025. IP: Ares A. Inv.Col: Ponjoan A.
  • Degree of agreement and predictive validity of the efragicap and fragile index-VIG instruments as a measure of frailty in elderly people treated in home care in Primary Health Care. ICS - Catalan Institute of Health. . 2022-2024. IP: Zamora JJ. Inv.Col: Basora J, Berenguera A, López T, Martínez C, Montero L, Ponjoan A, Salvador B.

Group publications

  • Lassale C, Lugon G, Hernáez A, Frank P, Marrugat J, Ramos R et al. Trajectories of antidepressant use and 6-year change in body weight: a prospective population-based cohort study. Front Psychiatry. 2024;151464898-1464898. PMID:39777198.
  • Aznar Lou I, Zabaleta Olmo E, Casajuana Closas M, Sánchez Viñas A, Parody Rúa E, Bolíbar B et al. Correction: Cost-effectiveness analysis of a multiple health behaviour change intervention in people aged between 45 and 75 years: a cluster randomized controlled trial in primary care (EIRA study). Int J Behav Nutr Phys Act. 2024;21(1):138-138. PMID:39654047.
  • Castells Nobau A, Puig I, Motger Albertí A, de la Vega correa L, Rosell Díaz M, Arnoriaga Rodríguez M et al. Microviridae bacteriophages influence behavioural hallmarks of food addiction via tryptophan and tyrosine signalling pathways. Nat Metab. 2024;6(11):2157-2186. PMID:39587339.
  • Coral DE, Smit F, Farzaneh A, Gieswinkel A, Delfin C, Tajes JF, Sparso T et al. Subclassification of obesity for precision prediction of cardiometabolic diseases. Nat. Med. 2024;PMID:39448862.
  • Romero V, Ponjoan A, Vidal M, Alves Cabratosa L, Pol Pons A. Breastfeeding Basic Competence in Primary Care: A Spanish Translation and Cross-Cultural Validation of the CAPA Questionnaire. J Hum Lact. 2024;40(4):512-521. PMID:39297356.
  • Gómez Sánchez M, Gómez Sánchez L, Ramos R, Rodríguez Sánchez E, García Ortiz L, Martí Lluch R et al. Relationship between the Mediterranean Diet and Vascular Function in Subjects with and without Increased Insulin Resistance. Nutrients. 2024;16(18):PMID:39339706.
  • Boal J, Ramos R, Martín C, Loma Osorio P, Palacio JC, Agudelo V et al. Evaluation of the ODISEA APP for improving a STEMI regional network. Int J Cardiol. 2024;410132217-132217. PMID:38830543.
  • NCD Risk Factor Collaboration (NCD-RisC),Ramos R. General and abdominal adiposity and hypertension in eight world regions: a pooled analysis of 837 population-based studies with 7·5 million participants. Lancet. 2024;404(10455):851-863. PMID:39216975.
  • Lugon G, Hernáez A, Jacka FN, Marrugat J, Ramos R, Garre Olmo J et al. Association between different diet quality scores and depressionrisk: the REGICOR population-based cohort study. Eur J Nutr. 2024;63(8):2885-2895. PMID:39180556.
  • Rosell Díaz M, Petit Gay A, Molas Prat C, Gallardo Nuell L, Ramió Torrentà L, Garre Olmo J et al. Metformin-induced changes in the gut microbiome and plasma metabolome are associated with cognition in men. Metab.-Clin. Exp. 2024;157155941-155941. PMID:38871078.
  • Young Silva Y, Berenguera A, Juvinyà Canal D, Martí Lluch R, Arroyo Uriarte P, Tamayo Morales O et al. Exploring personal aptitudes and personality traits that, together with social determinants, shape health behaviors and conduct: a thematic analysis based on the Capability, Opportunity, Motivation and Behavior (COM-B) change system. Front. Public Health. 2024;121387528-1387528. PMID:38898892.
  • Garcia Gil M, Alves Cabratosa L, Cunillera O, Blanch J, Martí Lluch R, Ponjoan A et al. Effectiveness of the low-density lipoprotein cholesterol goals in secondary cardiovascular prevention. Eur. J. Clin. Invest. 2024;54(9):PMID:38828496.
  • Gómez Sánchez L, Gómez Sánchez M, Tamayo Morales O, Lugones Sánchez C, González Sánchez S, Martí Lluch R et al. Relationship between the Mediterranean Diet and Metabolic Syndrome and Each of the Components That Form It in Caucasian Subjects: A Cross-Sectional Trial. Nutrients. 2024;16(12):PMID:38931300.
  • Bäck M, Topouchian J, Labat C, Gautier S, Blacher J, Cwynar M et al. Cardio-ankle vascular index for predicting cardiovascular morbimortality and determinants for its progression in the prospective advanced approach to arterial stiffness (TRIPLE-A-Stiffness) study. EBioMedicine. 2024;103105107-105107. PMID:38632024.
  • Rosell Díaz M, Santos González E, Motger Albertí A, Gallardo Nuell L, Arnoriaga Rodríguez M, Coll Martínez C et al. Lower serum ferritin levels are associated with worse cognitive performance in aging. J Nutr Health Aging. 2024;28(4):100190-100190. PMID:38368845.
  • Ponjoan A, Blanch J, Fages Masmiquel E, Martí Lluch R, Alves Cabratosa L, Garcia Gil MDM et al. Sex matters in the association between cardiovascular health and incident dementia: evidence from real world data. Alzheimers Res Ther. 2024;16(1):58-58. PMID:38481343.
  • Delfin C, Dragan I, Kuznetsov D, Tajes JF, Smit F, Coral DE et al. A Federated Database for Obesity Research: An IMI-SOPHIA Study. Life (Basel). 2024;14(2):PMID:38398771.
  • Camps Vilaró A, Pinsach Abuin M, Degano IR, Ramos R, Martí Lluch R, Elosua R et al. Genetic characteristics involved in COVID-19 severity. The CARGENCORS case-control study and meta-analysis. J Med Virol. 2024;96(2):PMID:38293834.
  • Zacarías Pons L, Turró Garriga O, Saez M, Garre Olmo J. Multimorbidity patterns and disability and healthcare use in Europe: do the associations change with the regional socioeconomic status?. Eur J Ageing. 2024;21(1):1-1. PMID:38170397.
  • Alves L, Elosua M, Martí R, Blanch J, Tornabell E, Garcia M, Ponjoan A, Grau M, Ribas F, Zacarías L, Ramos R. Cardiovascular Risk Age Reflects Arterial Status: Middle-Aged People Showed Equivalent Arterial Stiffness to Older People in the Same Risk Category. J Atheroscler Thromb. 2024;31(5):426-440. PMID:38171907.
  • NCD Risk Factor Collaboration (NCD-RisC), Ramos R. Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults. Lancet. 2024;S0140-6736(23):02750-02752. PMID:38432237.
  • NCD Risk Factor Collaboration (NCD-RisC), Ramos R. Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants. Lancet. 2024;S0140-6736(24):02317-1-02317-1. PMID:39549716
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