1. Annual Report 2025
  2. Research
  3. GRIP

GRIP

Infections in Primary Care Research Group

The group is made up of family physicians working in different lines of research on infectious diseases in primary care. We have collaborations with Catalan, Spanish and international universities and scientific societies of primary care in Catalonia and abroad. We actively participate in research by independent organizations in Catalonia, Spain and abroad. 

The primary objective of the group is to promote a more reasoned prescription of antimicrobials in primary care, identifying the subgroups of patients who really need them and avoiding them when they are not necessary.

Other objectives are the microbiological aspects of the most prevalent community germs, identifying whether the etiology is bacterial or viral, resistance and prognosis of the most common infections. Another objective is to provide the family physician with diagnostic tools for community infections by means of rapid diagnostic methods.

Group projects

  • Tailoring antibiotic therapy duration for uncomplicated respiratory tract infections that need antibiotic therapy. The pre-STORM qualitative study (Adaptació de la durada del tractament antibiòtic de les infeccions respiratòries no complicades que necessiten antibioteràpia. L'estudi qualitatiu pre-STORM). 2023-2026. IP: Ana Moragas Moreno.

  • Tailoring antibiotic duration for respiratory tract infections in primary care. A pragmatic randomised clinical trial [STORM Study]. (ICI24/00083). Institut d'Investigació en Atenció Primària Jordi Gol i Gurina (IDIAPJGol); Instituto de Salud Carlos III. 2025-2028. IP: Carles Llor Vilà.

  • Spanish primary care clinicians' attitudes towards point-of-care blood testing for respiratory tract infections in adults in primary care. A qualitative study. Abbott Rapid Diagnostics Healthcare S.L. 2024-2026. IP: Ana Moragas Moreno.

  • Preferencias en el uso de antibióticos en infecciones de orina no complicadas en mujeres adultas: Estudio cualitativo. Efectividad clínica y erradicación bacteriológica de 3 pautas antibióticas cortas y monodosis de fosfomicina trometamol en las infecciones urinarias bajas no complicadas en mujeres adultas (Estudio SCOUT). 2024-2027. IP: Carles Llor Vilà.

  • POS-ARI-PC-001: Study on the incidence of medically-attended respiratory syncytial virus, human metapneumovirus and human parainfluenza virus amongst older adults in Europe. ECRAID-Core. 2024-2027. IP: Carles Llor Vilà.

  • Platform randomised controlled trial of point of care diagnostics for enhancing the quality of antibiotic prescribing for community acquired acute respiratory tract infection in ambulatory care in Europe (PRUDENCE). University of Oxford. 2020-2025. IP: Carles Llor Vilà.

  • Perpetual Observational Study (POS) of Acute Respiratory Infections (ARI) in primary care settings (PC) across Europe - Audit. UMC Utrecht (University Medical Center Utrecht). 2023-2026. IP: Carles Llor Vilà.

  • Perception of best management of suspected lower urinary tract infection iin relation to national guidelines - an international study in primary health care / Percepción del mejor manejo de la sospecha de infección urinaria baja en relación con las guías nacionales: un estudio internacional en atención primaria. Göteborgs Universitet. 2025-2028. IP: Ana Moragas Moreno.

  • Percepción del mejor manejo en la sospecha de otitis media aguda en relación a las guías nacionales - Un estudio internacional en Atención Primaria de Salud. 2023-2025. IP: Carles Llor Vilà.

  • Percepción del mejor manejo en la sospecha de otitis media aguda en relación a las guías nacionales - Un estudio internacional en Atención Primaria de Salud. 2023-2025. IP: Carles Llor Vilà.

  • Pandemic Information to Support Rapid Response - PAIR. (101133191). European Commission. 2024-2028. IP: Carles Llor Vilà.

  • Maneig de les ITUS a Catalunya: estudi descriptiu del maneig diagnòstic i terapèutic, i l'impacte de les teràpies supressores en la gravetat d'infeccions potencialment greus [Estudi ITUCAT]. (SLT021/21/000022). Generalitat Catalunya. 2022-2025. IP: Ana Moragas Moreno.

  • Improving antibiotic use in long term care facilities by infection prevention and control and antibiotic stewardship (IMAGINE). European Commission. 2022-2026. IP: Carles Llor Vilà.

  • Grau d'Adequació en la Sol·licitud d'Urocultius Procedents d'Atenció Primària (WP4). Itucat. 2023-2026. IP: Ana Moragas Moreno.

  • First void OR Midstream Urine sampling among women with Lower urinAry tract infection symptoms. ICS - Institut Català de la Salut. 2022-2025. IP: Ana Moragas Moreno.

  • Factors predictors de pielonefritis aguda en persones que sofreixien una infecció del tracte urinari (WP3) - Estudi ITUCAT. 2024-2027. IP: Ana Moragas Moreno.

  • European Clinical Research Alliance on Infectious Diseases - Primary care adaptive platform trial for pandemics and epidemics (ECRAID-Prime). UMC Utrecht (University Medical Center Utrecht). 2023-2026. IP: Carles Llor Vilà.

  • Efectividad clínica y erradicación bacteriológica de 4 pautas antibióticas cortas en infecciones urinarias en mujeres adultas. estudio SCOUT. (ICI20/00100). Instituto de Salud Carlos III. 2020-2026. IP: Carles Llor Vilà.

  • Efectividad clínica y erradicación bacteriológica de 3 pautas antibióticas cortas y monodosis de fosfomicina trometamol en las infecciones urinarias bajas no complicadas en mujeres adultas [Estudio SCOUT]. (IJG-SCOUT-2021). Institut d'Investigació en Atenció Primària Jordi Gol i Gurina (IDIAPJGol). 2021IP: Carles Llor Vilà.

  • Optimització en l'ús d'antibiòtics per a les infeccions comunitàries en l'atenció primària GRIP. (SENIOR-23/2). ICS - Institut Català de la Salut. 2024-2028. IP: Carles Llor Vilà.

Group Publications

  • Moragas A, Cots JM, Llor C. Views of Spanish primary care professionals on respiratory tract infection testing: a qualitative study. BMJ Open. 2025;15(9):PMID:40921638.

  • Fernández Garcia S, Moragas A, Giner Soriano M, Morros R, Ouchi D, Garcia Sangenis A et al. Urinary tract infections in women in Catalonia, Spain: a population-based observational cohort study in primary care. Front. Pharmacol. 2025;161593910-1593910. PMID:40994650.

  • Llor C. The use of rapid tests beyond established clinical recommendations should be avoided entirely. Scand. J. Prim. Health Care. 2025;43(4):1-2. PMID:40405600.

  • Munné Barellas B, Monfà R, Llor C, Garcia Sangenís A, Miranda Jiménez C, Morros R et al. The Use of Antibiotics for Uncomplicated Urinary Tract Infections in Adult Women: Qualitative Findings From the SCOUT Trial. Patient Prefer. Adherence. 2025;192673-2685. PMID:40917820.

  • Lambert M, van Dijk L, Benko R, Llor C, Lykkegaard J, Mantel Teeuwisse AK et al. The role of the community pharmacist in antibiotic use-a commentary on current status and future perspectives. Explor. Res. Clin. Soc. Pharm. 2025;20100652-100652. PMID:40980189.

  • Monfà R, García Sangenís A, Morros R, Sáez CMZ, Mateos Nozal J, Pinto MNV et al. The impact of a multifaceted intervention on antibiotic use for common infections in nursing homes in Spain. A before and after study. Eur. Geriatr. Med. 2025;16(4):1465-1473. PMID:40261575.

  • Morros R, Moragas A, García Sangenís A, Monfà R, Miravitlles M, Vallejo Torres L et al. Tailoring Antibiotic Duration for Respiratory Tract Infections in Primary Care: Protocol fora Pragmatic Randomized Controlled Trial Study (STORM). JMIR RES. Protoc. 2025;14PMID:41115271.

  • Llor C. Shifting the mindset regarding adherence to antibiotic use for respiratory tract infections. Explor. Res. Clin. Soc. Pharm. 2025;18100588-100588. PMID:40166683.

  • Llor C, Hansen MP, Lykkegaard J, Lindberg BH. Overdiagnosis of community-acquired pneumonia in primary care. Comparison across five European countries. Aten. Prim. 2025;57(12):103273-103273. PMID:40513533.

  • Theut M, Jonsson A, Jensen JN, Antsupova V, Hansen MP, Llor C et al. Factors influencing urinary tract infection prevention and antibiotic stewardship in European nursing homes: an interview study with staff. Eur. Geriatr. Med. 2025;16(6):2293-2303. PMID:41117869.

  • Llor C, Ouchi D, Fernández García S, Giner Soriano M, Moragas A, Morros R. Exposure to suppressive antibiotic therapy in women with recurrent urinary tract infections and severity of infections: a retrospective population-based cohort study. BMJ Open. 2025;15(8): PMID:40819861.

  • García Sangenís A, Raynal Floriano F, López Valcárcel BG, Vallejo Torres L, Llor C, HAPPY PATIENT Study G. Effect of a multifaceted intervention on potentially unnecessary antibiotic prescriptions in general practice, out-of-hours services, and nursing homes in Spain. Rev. Esp. Quim. 2025;38(3):234-239. PMID:40145525.

  • Llor C, Hansen MP, Lykkegaard J, Olsen J, Lindberg BH, Rebnord IK et al. Duration of antibiotic treatment for respiratory tract infections in primary care. JAC-Antimicrob. Resist. 2025;7(1):PMID:40008154.

  • Lindberg BH, López Valcárcel BG, Olsen JK, Hansen MP, Lykkegaard J, Llor C et al. Diagnosing acute lower respiratory tract infections in out-of-hours services during the COVID-19 pandemic. Int. J. Emergency Medicine. 2025;18(1):138-138. PMID:40739482.

  • Llor C. C-reactive protein point-of-care testing to guide antibiotic prescribing for respiratory tract infections. Expert Rev. Respir. Med. 2025;19(8):1-15. PMID:40401764.

  • García Egea A, García Sangenís A, Llor C, Berenguera A, Moragas A, Monfà R et al. Clinicians' perspectives on a primary healthcare intervention to reduce antibiotic prescription for acute lower respiratory tract infections in Barcelona (Spain): a qualitative study. Prim. Health Care Res. Dev. 2025;26PMID:40611657.

  • Llor C, Frimodt Møller N. Can we rely on using penicillin as the first-line treatment of pneumonia in outpatient care?. Clin. Microbiol. Infect. 2026;32(1):13-15. PMID:41072659.

  • Kemper K, Abebe W, Bastos LSL, Berha AB, Bozza FA, Kesteman T et al. Best Practices for Addressing Differences in Antimicrobial Resistance Through Quality Improvement Projects in Antimicrobial Stewardship in Low-Resource Settings. Mayo Clin. Proc. 2025;100(10):1698-1702. PMID:40888787.

  • Xu A, Brown K, Schwartz KL, Aghlmandi S, Alderson S, Brehaut JC et al. Audit and Feedback Interventions for Antibiotic Prescribing in Primary Care: A Systematic Review and Meta-analysis. Clin. Infect. Dis. 2025;80(2):253-262. PMID:39657007.

  • Llor C, Olsen J, Lykkegaard J, Anastasaki M, Jensen JN, Sondergaard J et al. Assessment of potentially unnecessary antibiotic use for suspected urinary tract infections in nursing homes using a simplified algorithm. Expert Rev. Anti-Infect. Ther. 2025;23(2-4):1-7. PMID:39831536.

  • Fernandez Garcia S, Monfa R, Jimenez CM, Giner Soriano M, Gomez F, Moragas A. Appropriateness of urine culture requests in primary care in Spain: A cross-sectional descriptive study. Aten. Prim. 2025;57(7):103208-103208. PMID:39799637.

  • Hansen MB, Lykkegaard J, Hansen MP, Llor C, Sangenis AG, Touboul Lundgren P et al. Appropriateness of antibiotic use in nursing homes for suspected urinary tract infections: comparison across five European countries (vol 16, pg 1453, 2025). Eur. Geriatr. Med. 2025;17(1):407-407. PMID:40932593.

  • Hansen MB, Lykkegaard J, Hansen MP, Llor C, Sangenis AG, Touboul Lundgren P et al. Appropriateness of antibiotic use in nursing homes for suspected urinary tract infections: comparison across five European countries. Eur. Geriatr. Med. 2025;16(4):1453-1464. PMID:40146526.

Proceeding Papers

  • Munné Barellas B, Monfà R, Llor C, Garcia Sangenís A, Miranda Jiménez C, Morros Pedrós R et al. Preferences in the Use of Antibiotics for Uncomplicated Urinary Tract Infections in Adult Women: a Qualitative Study of a Clinical Trial (Scout). Gac. Sanit. 2025;39.

  • Glasova H, Glasa J, Llor C, Lykkegaard J, Hansen MP, Jensen JN et al. Improving antibiotic use in long-term care facilities (project IMAGINE): lessons learned from the first phase of the project implementation. Eur. J. Clin. Pharmacol. 2025;81(1):46-46.

  • Glasa J, Glasova H, Slezáková Z, Krcméryova T, Kollárová A, Fabiánová Z et al. Improving antibiotic use in long-term care facilities (project IMAGINE): a target country perspective (Slovakia). Eur. J. Clin. Pharmacol. 2025;81(1):43-43.

Anar a l'inici